Roles of flavonoids against coronavirus infection

M Russo, S Moccia, C Spagnuolo, I Tedesco… - Chemico-biological …, 2020 - Elsevier
… These polyproteins are processed by a main protease known as 3C-like-protease (3CL pro
… activity of recombinant SARS-CoV 3CL pro expressed in Pichia pastoris, a methylotrophic …

Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19

S Bhati, V Kaushik, J Singh - Journal of Molecular Structure, 2021 - Elsevier
… In the present study, a series of potential inhibitors targeting SARS-CoV 3CL protease
Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

Identification of Flavonoids as Potent Inhibitors Against MERS-CoV 3C-like Protease

F Abdi, S Javanshir - Coronaviruses, 2022 - ingentaconnect.com
… structure-activity relationships (SAR) of varied polyphenols against MERS-CoV 3C-like
Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris

Therapeutic potential of glycosyl flavonoids as anti-coronaviral agents

PIC Godinho, RG Soengas, VLM Silva - Pharmaceuticals, 2021 - mdpi.com
… processed by the virally encoded 3C-like protease (3CL pro )… binding affinities with the
protease were measured by ITC. The … these flavonoids to inhibit the interaction of the SARS CoV-2 …

Inhibition of SARS-CoV 3CL protease by flavonoids

S Jo, S Kim, DH Shin, MS Kim - Journal of enzyme inhibition and …, 2020 - Taylor & Francis
3C-like protease (3CLpro). Here, we applied a flavonoid library to systematically probe inhibitory
compounds against SARS-CoV … After that, we measured the fluorescence of the mixture …

Identification of two flavonoids antiviral inhibitors targeting 3C-like protease of porcine epidemic diarrhea virus

Z Li, L Zhu, L Wang, Y Huang, Y Zhang… - Frontiers in …, 2024 - frontiersin.org
… for combating coronaviruses. It is believed that certain flavonoids can directly inhibit the
3C-like protease (3CL pro ), thus displaying antiviral activity against coronaviruses. In this …

[HTML][HTML] Plant products as inhibitors of coronavirus 3CL protease

A Mandal, AK Jha, B Hazra - Frontiers in pharmacology, 2021 - frontiersin.org
… reported to inhibit coronavirus 3CL protease. Some of the plants like Isatis tinctoria L. (syn. …
inhibit coronavirus 3CL protease for development into approved antiviral drug against COVID-…

[PDF][PDF] The main protease of SARS-CoV-2 as therapeutic target to development specific drugs to treat COVID-19

RE Silva-lópez - J. Appl. Biotechnol. Bioeng. Rev, 2020 - pdfs.semanticscholar.org
… for SARS and MERS treatment may be used for COVID-19. The aim of this work is discuss the
molecular target of SARS-CoV-2, the main protease, … 82 %, expressed in Pichia pastoris. In …

Virtual screening of the flavonoids compounds with the SARS-CoV-2 3C-like protease as the lead compounds for the COVID-19

GP Adisurja, AA Parikesit - Coronaviruses, 2021 - ingentaconnect.com
… developing anti-SARS-CoV-2 lead … 3C-like Protease of the Coronavirus. Moreover, juglanin
was found as the compound with the fittest binding with the Protease enzyme of SARS-CoV-2…

[PDF][PDF] Are plant-derived flavonoids the emerging anti-coronavirus agents

FS Mohammad, MF Patwekar… - INNOSC …, 2022 - pdfs.semanticscholar.org
… the 3C-like protease (3CLpro) enzyme in coronaviruses can … the main protease of SARS-CoV,
MERS-CoV, and SARSCoV-2… expressed in Pichia pastoris [12]. Administration of quercetin …