Urease: structure, function, catalysis, and inhibition

L Mazzei, F Musiani, B Zambelli, S Benini, M Cianci… - Ureases, 2024 - Elsevier
… crystal structure of urease from (A) Sporosarcina pasteurii (… to match both thermodynamic
and kinetic experimental data. The … crystal structure of SPU inhibited in the presence of fluoride

Mechanism of urea decomposition catalyzed by Sporosarcina pasteurii urease based on quantum chemical calculations

J Zhu, D Shen, J Xie, C Tang, B Jin, S Wu - Molecular Simulation, 2021 - Taylor & Francis
… In 2019, fluoride is used as the co-substrate in the reaction … , and the crystal structure of the
urease – urea complex supports the ‘… inhibition structure (PDB code: 3UBP [Citation21]) of S. …

Exploration of urease-mediated biomineralization for defluoridation by Proteus columbae MLN9 with an emphasis on its genomic characterization

M Let, K Majhi, U Halder, A De, D Saha… - Journal of …, 2023 - Elsevier
… In the present study, we sought to isolate fluoride-resistant, urease producing bacteria from
Bacillus pasteurii ATCC11859 where the microbial growth and urease activity was inhibited

[HTML][HTML] Recent advances in design of new urease inhibitors: A review

P Kafarski, M Talma - Journal of advanced research, 2018 - Elsevier
… complexes with various inhibitors. Such structures have been determined and deposited in
Protein Data Bank. The most of them consider Sporosarcina pasteurii urease complexes with …

Inactivation of urease by catechol: Kinetics and structure

L Mazzei, M Cianci, F Musiani, G Lente… - Journal of Inorganic …, 2017 - Elsevier
… Therefore, efficient urease inhibitors are actively sought. In this study, we describe a molecular
characterization of the interaction between urease from Sporosarcina pasteurii (SPU) and …

Thermodynamic study of competitive inhibitors' binding to urease

B Krajewska, M Brindell - Journal of Thermal Analysis and Calorimetry, 2016 - Springer
thermodynamic urease inhibition data. However, as mentioned earlier the reports on the
thermodynamics of urease inhibition … The available data are those on heavy metal ions inhibition

Jack bean urease

A Balasubramanian, K Ponnuraj - Ureases, 2024 - Elsevier
Bacillus pasteurii urease (BPU) and Klebsiella aerogenes … structures of KAU and BPU, it
was proposed that fluoride binds … The urease structure with fluoride as an inhibitor had not …

… inhibition of ureolytic activity and growth of Klebsiella pneumoniae in vitro suggests cobinding of fluoride and acetohydroxamic acid at the urease active site and …

S Svane, MC Lyngsie, JK Klitgaard, H Karring - Heliyon, 2024 - cell.com
urease inhibitors fluoride (F − ) and acetohydroxamic acid (AHA). The concentration of AHA
needed for efficient inhibition … is coapplied with tannic acid and sodium fluoride (NaF). Thus, …

Insights into Urease Inhibition by N-(n-Butyl) Phosphoric Triamide through an Integrated Structural and Kinetic Approach

L Mazzei, M Cianci, U Contaldo… - Journal of agricultural and …, 2019 - ACS Publications
… The development of ever more efficient urease inhibitors demands knowledge of … structure
of the enzyme–inhibitor complex obtained upon incubation of Sporosarcina pasteurii urease (…

Inhibition mechanism of urease by Au (III) compounds unveiled by X-ray diffraction analysis

L Mazzei, MN Wenzel, M Cianci… - ACS Medicinal …, 2019 - ACS Publications
inhibition effects with IC 50 values in the nanomolar range. The 2.14 Å resolution crystal
structure of Sporosarcina pasteurii urease inhibited … (40) sulfite, (41) and fluoride, (42) as well as …