… and its efficacy as a chemopreventive. This chapter presents this … intraepithelial neoplasia
and as an inhibitor to cancer cells of … The results of the study established that middle-aged men …

… High-grade prostatic intra-epithelial neoplasia represents the … agents such as nilutamide,
flutamide and bicalutamide. The … Chemoprevention Chemoprevention is defined as the …

… options for men diagnosed with localized prostate cancer: … Anti-androgens, such as
flutamide, bicalutamide and … increasing the incidence of prostatic intraepithelial neoplasia (PIN). …

… been observed in patients undergoing flutamide treatment. AR … in normal prostatic epithelial
cells and in cells with prostatic … ‐blinded and placebo‐controlled clinical trial was conducted …

… Unfortunately, invariably within two years most of these men develop what is known as
castration-resistant prostate cancer (CRPC) due to an aberrant reactivation of the androgen/AR …

… study of 9,457 men aged !55 years at randomization and estimated the multivariableadjusted
HR of prostate cancer (… A controlled trial leuprolide with and without flutamide in prostatic …

… and least understood solid neoplasm diagnosed in men. It is a … in PC-3 cells and PrEC
(prostate epithelial) normal cells. The … also explored for chemoprevention and treatment of cancer. …

… in males, both in the world and in our country. Current therapeutic approaches for prostate
cancer … chemopreventive intervention of those cancers remains one of the important issues in …

… The Prostate is part of the male reproductive tract responsible to produce main parts of the
… to binding through progesterone, estrogen, flutamide, bicalutamide, and enzalutamide by …

… to prove in comparison to man-made drugs developed for … treatment of prostate cancer,
and the activity of flutamide was … in relation to chemopreventive potential as well (Table S4). …