… by the efficacy of anti-IgE therapy in many clinical trials on … from the discovery of IgE 50 y
ago, followed by studies of IgE … of anti-IgE therapy and other strategies targeting IgE and its …

… the dose from IgE levels after initiating treatment from the study groups, and there is no
specific recommendation for revising the dosage of omalizumab from the manufacturer. …

… between IgE-Fc and a Fab derived from omalizumab. The … IgE-Fc, revealing the mechanism
of action of omalizumab, both for receptor inhibition and accelerated dissociation of IgE from …

… The current meta-analysis provided evidence of the efficacy of OMA in patients with IgE-mediated
FA and corroborates the findings from individual studies that OMA can enable …

… of action and effectiveness of omalizumab against major IgE related diseases; adult and …
Omalizumab can actively dissociate IgE from FcεRI, albeit at concentrations higher than …

… IgE by more than 95%. From a clinical point of view, therapy with omalizumab reduces asthma
… and the use of rescue medication in adults and children suffering from allergic asthma. …

… of the omalizumab–Fab in complex with an IgE-Fc … from the crystal structure, we
produced an additional IgE-Fc 3–4 mutant. IgE residue R419 lies at the interface of the IgE:omalizumab …

… from patients treated with omalizumab who showed or lacked hypersensitivity reactions.
Data from … the patient population treated with omalizumab. Data collected included clinical …

… individual mice with bars indicating mean ± SEM pooled from 2 (FcγR null ; … omalizumab/IgE
ICs can activate neutrophils through engagement of FcγRs. We purified neutrophils from …

… In 2015, there are currently data from 23 total serum IgE assays and 10 allergen-specific
IgE assays reported in a widely-subscribed North American national proficiency survey. …