[HTML][HTML] Cellular heterogeneity: Yeast-side story

S Pinheiro, S Pandey, S Pelet - Fungal Biology Reviews, 2022 - Elsevier
… heterogeneity allows the emergence of different phenotypes … of the whole complex. Therefore,
the proper function of the … coli, transcription factors are clearly expressed at lower levels …

Yeast Systems Biology: The Continuing Challenge of Eukaryotic Complexity

SG Oliver - Yeast Systems Biology: Methods and Protocols, 2019 - Springer
… genes by the altered phenotypes of mutant organisms and … The nuclear membrane
segregates the site of transcription … This was an important lesson in that it demonstrated that the …

Fungal evolution: cellular, genomic and metabolic complexity

MA Naranjo‐Ortiz, T Gabaldón - Biological Reviews, 2020 - Wiley Online Library
… In this review, we discuss recent advances in our understanding of the evolution of
phenotypic and genomic complexity within the fungal kingdom, focusing on the cellular and …

[HTML][HTML] Aspects of Multicellularity in Saccharomyces cerevisiae Yeast: A Review of Evolutionary and Physiological Mechanisms

M Opalek, D Wloch-Salamon - Genes, 2020 - mdpi.com
… acquired the adhesion phenotype of the wild yeast strain [14]… a quiescence-related
transcriptional program that can involve … What we learn about selection for multicellularity in yeast

The complex genetic basis and multilayered regulatory control of yeast pseudohyphal growth

A Kumar - Annual Review of Genetics, 2021 - annualreviews.org
… Flo8p heterodimerizes with the Mss11p transcription factor (66), and both FLO8 and …
phenotypes in yeast pseudohyphal growth (11). Flo8p functions as part of a complex transcriptional

[HTML][HTML] ALS yeast models—past success stories and new opportunities

SE Di Gregorio, ML Duennwald - Frontiers in Molecular Neuroscience, 2018 - frontiersin.org
… and yeast the HSR is regulated primarily by the transcription … also characterized in yeast
with similar phenotypes. They found … Many of the complex mechanisms underlying ALS onset …

Candida albicans: an emerging yeast model to study eukaryotic genome plasticity

M Legrand, P Jaitly, A Feri, C d'Enfert, K Sanyal - Trends in Genetics, 2019 - cell.com
… A phenotypic switch from white to opaque form … transcription factors responsible for cellular
identity are shown in red, while the OBP, PAP, and PIK genes that are not involved in cellular

The landscape of transcription errors in eukaryotic cells

JF Gout, W Li, C Fritsch, A Li, S Haroon, L Singh… - Science …, 2017 - science.org
… select the correct substrates out of complex mixtures of countless … of the yeast transcriptome
and found >200,000 transcription … could influence cellular phenotypes via mechanisms other …

Experimental evolution reveals favored adaptive routes to cell aggregation in yeast

EA Hope, CJ Amorosi, AW Miller, K Dang, CS Heil… - Genetics, 2017 - academic.oup.com
… loss-of-function mutations in transcriptional repressor TUP1, which … To test causality, and
examine the genetic complexity of the trait … from each phenotypic class revealed cosegregating …

Yeast systems biology: model organism and cell factory

J Nielsen - Biotechnology journal, 2019 - Wiley Online Library
… far more complex transcriptional regulation in yeast than previously … approach for acquiring
new phenotypes such as improved … This study clearly shows how machine learning can be a …