Micro-computed tomography imaging of cigarette smoke-exposed mice to model early chronic obstructive pulmonary disease (COPD)

NL Ford, I Lee, A Tam, DD Sin - … , and Functional Imaging, 2019 - spiedigitallibrary.org
… requires modeling COPD in rodents. Models have emerged … structural and functional
information about the lung organ (… to the structure and function of lungs following acute (1-month…

Deep Learning–based Automatic Lung Segmentation on Multiresolution CT Scans from Healthy and Fibrotic Lungs in Mice

F Sforazzini, P Salome, M Moustafa, C Zhou… - Radiology: Artificial …, 2022 - pubs.rsna.org
Rodent animal models are established for the preclinical study of pathophysiologic processes
involved in the development of lung fibrosis, … , structural, and functional imaging. Vol 7965.…

Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models

N Berghen, K Dekoster, E Marien, J Dabin, A Hillen… - Scientific reports, 2019 - nature.com
… on lungs or blood cells, while maintaining high image quality … (lung) disease processes and
host responses in rodent models… function of signal intensity intrinsic to lung metastasis grade. …

Distal lung epithelial progenitor cell function declines with age

JK Watson, P Sanders, R Dunmore, G Rosignoli… - Scientific Reports, 2020 - nature.com
… We examine the gross morphological changes in these lungs, the number and function of …
Given that the human lifespan is far longer than the rodent lifespan, it will be interesting to …

Effects of nintedanib on the microvascular architecture in a lung fibrosis model

M Ackermann, YO Kim, WL Wagner, D Schuppan… - Angiogenesis, 2017 - Springer
… trend toward improvement in lung function and inflammation. … effect of nintedanib on lung
function and inflammation. These … to quantify fibrotic changes in rodents with μCT, and to avoid …

Nintedanib reduces radiation-induced microscopic lung fibrosis but this cannot be monitored by CT imaging: a preclinical study with a high precision image-guided …

D De Ruysscher, PV Granton, NG Lieuwes… - Radiotherapy and …, 2017 - Elsevier
… Recently, it has also become established that the heart and the lungs are integral functional
Rodent studies and retrospective series in patients suggest that captopril, an angiotensin-…

Comparative analysis of the mechanical signals in lung development and compensatory growth

CCW Hsia - Cell and tissue research, 2017 - Springer
… and function in chronic destructive lung diseases, transplantation and bioengineered … to
the more widely studied rodent model: First, patterns of rib cage, lung and somatic maturation in …

The cellular and physiological basis for lung repair and regeneration: past, present, and future

MC Basil, J Katzen, AE Engler, M Guo, MJ Herriges… - Cell stem cell, 2020 - cell.com
… of lung repair and regeneration. We focus on the cellular compositions within functional niches,
… to injury, and new methods to study lung repair and regeneration. We also provide future …

Hyperpolarized 129Xe magnetic resonance spectroscopy in a rat model of bronchopulmonary dysplasia

JD Fliss, B Zanette, Y Friedlander… - … of Physiology-Lung …, 2021 - journals.physiology.org
… the lungs during a breath-hold (8). HP gas MRI has been safely and tolerably used for functional
lung imaging in … Term rodents are particularly appropriate as they are born at a stage of …

[HTML][HTML] The use of PET imaging for prognostic integrin α2β1 phenotyping to detect non-small cell lung cancer and monitor drug resistance responses

CW Huang, WC Hsieh, ST Hsu, YW Lin, YH Chung… - Theranostics, 2017 - ncbi.nlm.nih.gov
imaging can offer a valuable and critical diagnostic imaging criterion for the identification of
phenotypes of aggressive lung … α2β1, several quantitative and functional in vitro assays were …