Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury
B Yu, X Gu - Frontiers of Medicine, 2019 - Springer
… : (1) injury-induced gliosis and … rats, and findings showed significant recovery of functional
motor skills [29]. One of the most successful cases involved the utilization of fibrin as a matrix …
motor skills [29]. One of the most successful cases involved the utilization of fibrin as a matrix …
[HTML][HTML] Intravenous infusion of adipose-derived stem/stromal cells improves functional recovery of rats with spinal cord injury
Y Ohta, A Hamaguchi, M Ootaki, M Watanabe… - Cytotherapy, 2017 - Elsevier
… A RayBio rat cytokine antibody array (RayBiotech) was used … led us to hypothesize that
grafted ASCs accumulated at the … Although partly statistically not significant, both augmented …
grafted ASCs accumulated at the … Although partly statistically not significant, both augmented …
Grafting embryonic raphe neurons reestablishes serotonergic regulation of sympathetic activity to improve cardiovascular function after spinal cord injury
S Hou, TM Saltos, E Mironets… - Journal of …, 2020 - Soc Neuroscience
… site of completely transected rat spinal cord. Consequently, … The tissue blocks were then
resuspended in a fibrin matrix (… , did not affect injury-induced hypotension or tachycardia. We …
resuspended in a fibrin matrix (… , did not affect injury-induced hypotension or tachycardia. We …
Pathophysiology of spinal cord injury
LD Hachem, MG Fehlings - Neurosurgery Clinics, 2021 - neurosurgery.theclinics.com
… and temporal integration of injury-induced signaling cascades, … to cumulative improvements
after spinal cord injury in rats. … seen in neurogenic bladders after SCI and P2X3 antagonists …
after spinal cord injury in rats. … seen in neurogenic bladders after SCI and P2X3 antagonists …
Animal models for treating spinal cord injury using biomaterials-based tissue engineering strategies
JJ Li, H Liu, Y Zhu, L Yan, R Liu, G Wang… - … Engineering Part B …, 2022 - liebertpub.com
… Significantly reduced injury-induced demyelination and … rat NSCs Significantly improved
locomotion recovery; grafted … gradually in rats within 8 weeks, after which functional scores …
locomotion recovery; grafted … gradually in rats within 8 weeks, after which functional scores …
[HTML][HTML] Mesenchymal stem cells in treatment of spinal cord injury and amyotrophic lateral sclerosis
E Sykova, D Cizkova, S Kubinova - Frontiers in cell and …, 2021 - frontiersin.org
… , including human decellularized extracellular matrix (ECM) or … of a rat spinal cord with acute
balloon-induced spinal cord … the improvement of the hind limb function and bladder control. …
balloon-induced spinal cord … the improvement of the hind limb function and bladder control. …
Traumatic spinal cord injury
… the spinal cord can result in partial or complete loss of function … proliferate and deposit
extracellular matrix molecules into the … Rat models are the most commonly used for SCI research …
extracellular matrix molecules into the … Rat models are the most commonly used for SCI research …
[HTML][HTML] … effect of collagen and fibrin hydrogels encapsulated with adipose tissue mesenchymal stem cell-derived exosomes for treatment of spinal cord injury in a rat …
… ( 5 - 10 ), effective functional recovery has yet to be introduced. … , damage of the extracellular
matrix, and hypoxic ischemia is … for the treatment of nerve injury-induced pain in rats ( 54 ). …
matrix, and hypoxic ischemia is … for the treatment of nerve injury-induced pain in rats ( 54 ). …
Perspectives in the cell-based therapies of various aspects of the spinal cord injury-associated pathologies: Lessons from the animal models
M Zawadzka, A Kwaśniewska, K Miazga, U Sławińska - Cells, 2021 - mdpi.com
… In the rat model of spinal cord compression, grafting … cells, leading to functional recovery of
grafted animals manifested by … However, the injury-induced secretome was produced within a …
grafted animals manifested by … However, the injury-induced secretome was produced within a …
Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
… rat models of stroke, cortical ablation, parkinsonism and … related to the cell transplant or
the intramedullary injection … improvements in fine motor function when assessed using the …
the intramedullary injection … improvements in fine motor function when assessed using the …