… Of interest was enrichment of the chemokine signaling … feedback loop in which diabetogenic
pro-inflammatory cytokines … recruitment of cytotoxic CD8+ T lymphocytes and macrophages. …

… Therefore transient antibody targeting of CXCR3 signalling … and their receptors in recruitment
of immune cells to sites of … within the islet infiltrate are CD8 cytotoxic T cells (CTL) and B …

… CXCL10 attracts especially Th1 cells and cytotoxic CD8 T … The necessity of the CXCR3/CXCL10
axis in diabetes … corroborates a functional role for CXCL10 in T-cell recruitment in islets …

… Biglycan can signal through differential TLR2/4 signaling pathways involving the TLR …
CXCR3/CXCL10 axis there might be other mechanisms for biglycan-mediated T cell recruitment…

… established, redundant pathways for T cell recruitment allow … receptor signaling on T cells
is necessary for T cell recruitment … shown to be chemorepulsive to diabetogenic T cells in vitro …

… The analysis of downstream signaling pathways indicated that apoptosis is p38 MAPK-…
functional role of CXCR3/CXCL10 in mediating T cell recruitment to the inflammatory site in OLP. …

… can be lost following sufficient immune cell recruitment to the peri-islet … A miR181a-mediated
increase in signal strength of … that B cells function to promote the survival of cytotoxic T cells …

… These data reinforce that chemokine receptor signaling is highly redundant for T … recruit T
cells via chemokine production. To confirm that chemokine signaling is required for recruitment …

… Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic
cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model. …

… The CXCR3/CXCL10 axis has been proposed as a key player in the infiltration of autoreactive
T cells into the pancreatic islets followed by the destruction of β cells. Combining the …