Experimental early‐life febrile seizures cause a sustained increase in excitatory neurotransmission in newborn dentate granule cells

G Hoogland, M Raijmakers, E Clynen… - Brain and …, 2022 - Wiley Online Library
… -associated temporal lobe epilepsy. The dentate gyrus is the … Febrile seizures (FS) are
fever-induced seizures in children till … Since GABA has an initial depolarizing effect on newborn …

[HTML][HTML] Seizure-induced hilar ectopic granule cells in the adult dentate gyrus

Y Kasahara, H Nakashima, K Nakashima - Frontiers in Neuroscience, 2023 - frontiersin.org
… of seizure-induced ectopic granule cells in the epileptic brain. In … decreased it in a postnatal
febrile seizure (which is thought … Following epileptogenic insults, GABAergic interneurons are …

Experimental febrile seizures increase dendritic complexity of newborn dentate granule cells

M Raijmakers, E Clynen, N Smisdom, S Nelissen… - …, 2016 - Wiley Online Library
… A subgroup of these children later develops epilepsy … clear whether these cells reflect
normotopic or ectopic cells, it … experimental FS induction presumably by excitatory GABA

The pharmacological assessment of GABAA receptor activation in experimental febrile seizures in mice

Y Kasahara, H Igata, T Sasaki, Y Ikegaya, R Koyama - eneuro, 2019 - eneuro.org
… , where immature neurons overwhelm mature neurons. Using experimental approaches
in … GABA A receptor modulators increase epileptic events 10 min after the induction of …

[PDF][PDF] Microglial displacement of GABAergic synapses is a protective event during complex febrile seizures

Y Wan, B Feng, Y You, J Yu, C Xu, H Dai, BD Trapp… - Cell Reports, 2020 - cell.com
… The GABAergic excitation after complex FSs also induces granule cell ectopia and promotes
the development of epilepsy during adulthood (Koyama et al., 2012). Inflammation is also …

The Role of Hyperexcitable Existing Granule Cells in Seizure-Induced Ectopic Granule Cells

H Tan - MedScien, 2024 - deanfrancispress.com
… Therefore, this paper concentrates on GABA receptors, … of ectopic GCs in the aftermath of
experimental febrile seizures. … between seizures, adult neurogenesis, and their role in epilepsy. …

Dentate circuitry as a model to study epileptogenesis

R Koyama - Biological and Pharmaceutical Bulletin, 2016 - jstage.jst.go.jp
… of epilepsy in a rat model of complex febrile seizures. … granule cells is attenuated by febrile
seizures, and these … enhanced excitatory GABAergic inputs to the migrating granule cells. …

[HTML][HTML] The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

Y Yi, C Zhong, H Wei-Wei - … in Cell and Developmental Biology, 2023 - frontiersin.org
… of FSs with epilepsy in adult, with numbers of … granule cells resulted in granule cell
ectopia that persists into adulthood. FSs induced an upregulation of GABA (A) receptors [GABA

Febrile Response and Seizures

A Vezzani, T Bartfai - Stress: Physiology, Biochemistry, and Pathology, 2019 - Elsevier
… Although most febrile seizures are benign, prolonged febrile seizures increase the risk of …
by bumetanide after FS rescued the ectopic granule cells as well as development of epilepsy in …

Neurogenesis and dentate granule cell development in epilepsy

BE Hosford, SC Danzer - Neural Stem Cells in Health and Disease, 2016 - World Scientific
… developed epilepsy following status epilepticus induced by … , hilar ectopic granule cells do
receive increased tonic GABA … animal model of prolonged febrile seizures. Hippocampus 13(3)…