[PDF][PDF] GABAergic Neurotransmission Abnormalities inPharmacoresistant Epilepsy: Experimental andHuman Studies

IAFR SandraOrozco-Suárez - Pharmacoresistance in Epilepsy - researchgate.net
… Based on experimental and clinical studies, epilepsy-induced … with generalized epilepsy
with febrile seizures plus type 3 (GEFS… of GABA a receptor subunits on dentate granule cell

[HTML][HTML] Adenosine A2A receptors control synaptic remodeling in the adult brain

X Xu, RO Beleza, FQ Gonçalves, S Valbuena… - Scientific Reports, 2022 - nature.com
… This involves A 2A R located in dentate granule cells since … MF in epileptic rats 20 and a
SE-induced increased activity of … also play a key role in GABAergic synapses stabilization 20 . …

The role of epigenetics in the pathophysiology of epilepsy

SM Nam, KO Cho - Neuropsychiatric Disorders and Epigenetics, 2017 - Elsevier
epilepsy and histologic alterations induced by acute seizures… role of ectopic granule cells
was confirmed in febrile seizure-… for the proper functioning of GABAergic interneurons in the …

Adult neurogenesis in the development of epilepsy

SC Danzer - Epilepsy Currents, 2019 - journals.sagepub.com
… newborn granule cells 5 weeks prior to pilocarpine-induced … in the granule cell body layer,
while others migrate to ectopicgranule cells after the development of clinical epilepsy would …

[引用][C] Molecular Genetics of Acquired Temporal Lobe Epilepsy. Biomolecules 2024, 14, 669

AM Neumann, S Britsch - 2024

[HTML][HTML] Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice

H Moriyama, S Nomura, H Imoto, F Oka… - Frontiers in …, 2023 - frontiersin.org
… can increase the risk of epilepsy development. Therefore, … After performing a scalp incision,
we created two slits in the … Menthol reduces the excitation of rat hippocampal neurons …

Neurodegenerative pathways as targets for acquired epilepsy therapy development

PM Casillas‐Espinosa, I Ali, TJ O'Brien - Epilepsia Open, 2020 - Wiley Online Library
… of GABAergic interneuron basket cells and with granule cells.… kainic acid-induced post-SE
model of acquired epilepsy.188 … be detected within hours up to 2.5 years after TBI.181-183 …

[HTML][HTML] Neuronal K+-Cl- cotransporter KCC2 as a promising drug target for epilepsy treatment

E McMoneagle, J Zhou, S Zhang, W Huang… - Acta Pharmacologica …, 2024 - nature.com
… results in GABAergic excitation associated with epileptic activity… KCC2 protein in denervated
granule cell dendrites. Furthermore… in the KCC2 gene in the development of febrile seizures. …

Reelin, tau phosphorylation and psychiatric complications in patients with hippocampal sclerosis and structural abnormalities in temporal lobe epilepsy

RA Machado, V Benjumea-Cuartas, JFZ Berruecos… - Epilepsy & Behavior, 2019 - Elsevier
… type IIIa have history of febrile seizures. These data would indicate … a substantial granular
cell loss (granular cell pathology type 1… Reelin is hypermethylated in GABAergic neurons of …

Multimodal GABAA receptor functions in the development of the central nervous system

T Kumada, A Fukuda - Synapse development and maturation, 2020 - Elsevier
… in the adult cerebellar granule cells: GABA A receptors … with GABA A receptor and etiology
of epilepsy in this section. … suggesting that febrile seizureinduced excitatory GABA A receptor …