Spatiotemporal regulators for insulin‐stimulated GLUT4 vesicle exocytosis

X Zhou, P Shentu, Y Xu - Journal of Diabetes Research, 2017 - Wiley Online Library
GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction
of insulin‐regulated GLUT4 … spatiotemporal regulation of GLUT4 vesicle exocytosis is of …

RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis

DR Gulbranson, EM Davis… - Proceedings of the …, 2017 - National Acad Sciences
… RABIF binds to Rab10, an exocytic Rab GTPase regulating GLUT4 exocytosis, and robustly
… in GLUT4 exocytosis. Instead, our results suggest that RABIF regulates GLUT4 exocytosis by …

Genetic evidence for an inhibitory role of tomosyn in insulin‐stimulated GLUT4 exocytosis

S Wang, Y Liu, L Crisman, C Wan, J Miller, H Yu… - Traffic, 2020 - Wiley Online Library
… We observed that tomosyn bound to GLUT4 exocytic t-SNAREs and arrested the fusion …
SNARE complexes involved in GLUT4 exocytosis. Tomosyn was removed from GLUT4 exocytic t-…

[PDF][PDF] Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis

S Wang, L Crisman, J Miller, I Datta… - Journal of Biological …, 2019 - ASBMB
… We observed that insulin-stimulated GLUT4 exocytosis was … role in insulin-stimulated GLUT4
exocytosis in adipocytes. We … glucose transporter GLUT4 (1–3). Under basal conditions, …

A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

Y Sun, J Jaldin-Fincati, Z Liu, PJ Bilan… - Molecular biology of the …, 2016 - Am Soc Cell Biol
… Of note, GLUT4 associated with the … with GLUT4. Our findings suggest that MICAL-L2 is
an effector of insulin-activated Rab13, which links to GLUT4 through ACTN4, localizing GLUT4

[HTML][HTML] Thirty sweet years of GLUT4

A Klip, TE McGraw, DE James - Journal of Biological Chemistry, 2019 - ASBMB
GLUT4 discovery and chronicle additional key findings made in the past 30 years. That
exocytosis of … GLUT4 controls glucose transport into fat and muscle tissues in response to insulin …

Update on GLUT4 vesicle traffic: a cornerstone of insulin action

JR Jaldin-Fincati, M Pavarotti, S Frendo-Cumbo… - Trends in Endocrinology …, 2017 - cell.com
… Under basal conditions GLUT4 recycles constitutively through endocytosis and exocytosis
as it moves from the PM to the early endosomes (EE) and from the EE to the recycling …

A detection method for GLUT4 exocytosis based on spontaneous split luciferase complementation

M Endo, M Miyasaki, Q Li, G Kawamura… - Analytical …, 2019 - jstage.jst.go.jp
… of GLUT4, quantitative measurement of GLUT4 exocytosis is indispensable. Herein, we show
a rapid detection system for GLUT4 … Upon insulin-induced GLUT4 exocytosis, GLUT4 was …

[PDF][PDF] GLUT4 mobilization supports energetic demands of active synapses

G Ashrafi, Z Wu, RJ Farrell, TA Ryan - Neuron, 2017 - cell.com
… Thus, we conclude that AMPK-driven GLUT4 exocytosis is … exocytosis on GLUT4 trafficking.
An important consideration, however, in examining the molecular basis of GLUT4 exocytosis

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking

M Uhm, M Bazuine, P Zhao, SH Chiang, T Xiong… - Science …, 2017 - science.org
… Thus, both the S8A and S8E mutants block GLUT4 exocytosis because of their ability to
prevent the assembly or disassembly of the exocyst complex, respectively. These observations …