GLUT4 On the move

DJ Fazakerley, F Koumanov, GD Holman - Biochemical Journal, 2022 - portlandpress.com
… two exocytotic routes to the PM, one from a sequestered GLUT4GLUT4 exocytosis mainly
occurs through the recycling endosome route (≈20% of GLUT4), with the bulk of the GLUT4 (…

[HTML][HTML] Prior exercise in humans redistributes intramuscular GLUT4 and enhances insulin-stimulated sarcolemmal and endosomal GLUT4 translocation

JR Knudsen, DE Steenberg, JR Hingst… - Molecular …, 2020 - Elsevier
GLUT4 to reflect a greater amount of pre-docked GLUT4 vesicles close to the T-tubuli rather
than fully inserted GLUT4 … changes in GLUT4 translocation reflect changes in exocytosis and/…

Exocytosis proteins: typical and atypical mechanisms of action in skeletal muscle

J Hwang, DC Thurmond - Frontiers in Endocrinology, 2022 - frontiersin.org
… This is particularly relevant to the skeletal muscle field, since STX4 is the sole STX family
member identified in the process of GLUT4 exocytosis. No redundant PM-localized alternate …

PKC and Rab13 mediate Ca2+ signal-regulated GLUT4 traffic

B Deng, X Zhu, Y Zhao, D Zhang, A Pannu… - Biochemical and …, 2018 - Elsevier
exocytosis of GLUT4 is partly reversed by siPKCθ, whereas ionomycin-inhibited endocytosis
of GLUT4 … In summary, PKCθ regulates GLUT4 exocytosis in response to ionomycin, …

[HTML][HTML] Focus: Organelles: Glut4 storage vesicles: Specialized organelles for regulated trafficking

DT Li, EN Habtemichael, O Julca, CI Sales… - The Yale journal of …, 2019 - ncbi.nlm.nih.gov
… If GSVs are one example of a more general organelle for regulated exocytic translocation,
as we propose, then cytosolic signals similar to those on GLUT4 may be present on other …

Exocytosis proteins as novel targets for diabetes prevention and/or remediation?

A Aslamy, DC Thurmond - American Journal of Physiology …, 2017 - journals.physiology.org
… Although all groups agree fully that DOC2B plays a positive role in regulating insulin-stimulated
GLUT4 vesicle exocytosis and SNARE complex formation, DOC2B’s mechanism(s) of …

Measurement of GLUT4 traffic to and from the cell surface in muscle cells

CN Antonescu, S Ishikura, PJ Bilan, A Klip - Current Protocols, 2023 - Wiley Online Library
GLUT4 exocytosis measurements in the presence of insulin at each timepoint were normalized
to the corresponding timepoint of the basal state and shown ± SE in panel ii. Note that in …

Autophagy and GLUT4: The missing pieces

SAM Elhassan, M Candasamy, EWL Chan… - Diabetes & Metabolic …, 2018 - Elsevier
… Here, it has been discussed about how autophagy can act as a transporter for GLUT4. In
line with mentioned evidences, the internalization and exocytosis processes of GLUT4 and …

Glut4 is sorted from a Rab10 GTPase-independent constitutive recycling pathway into a highly insulin-responsive Rab10 GTPase-dependent sequestration pathway …

PD Brewer, EN Habtemichael, I Romenskaia… - Journal of Biological …, 2016 - ASBMB
Glut4 exocytosis (k ex ), although Rab10 knockdown also caused a 1.4-fold increase in the
rate constant of Glut4 … is an AS160 substrate that limits exocytosis through the highly insulin-…

Phosphorylation of Syntaxin 4 by the insulin receptor drives exocytic SNARE complex formation to deliver GLUT4 to the cell surface

D Kioumourtzoglou, HL Black, M Al Tobi, R Livingstone… - Biomolecules, 2023 - mdpi.com
… This is achieved through an increase in the exocytic trafficking rate of the facilitative glucose
transporter GLUT4 from intracellular stores to the cell surface. Delivery of GLUT4 to the cell …