… local HSV-TK/ganciclovir-mediated suicide gene therapy of an … -TK gene expression level
in human esophageal cancer cell … innovative rat models with orthotopic esophageal cancers, …

… of brain tumors given our current understanding of their mechanisms. … -mediated transfer
of the HSVTK gene into primary brain tumors followed by systemic treatment with ganciclovir (…

… mediated cell death associated with GCV, BVDU, and a combinatorial drug treatment, 1:1
HSV/TK + and wild-type NPCs expressing … -TK expressing NPCs were transplanted into a rat …

… for rats with brain tumors treated with the hrR3 HSV vector in the the presence or absence of
ganciclovir. The … immunity following thymidine kinase-mediated killing of experimental brain …

… in injected tumors and a secondary immune-mediated antitumor … upregulate endogenous
thymidine kinase (TK), providing … to treatment with acyclovir or ganciclovir, which requires phos…

… Background: Glioblastoma multiform (GBM) as a malignant brain tumor has … -mediated
herpes simplex virus thymidine kinase (HSV-TK) gene at frontal focus of tumor besides ganciclovir …

… that STAT1/3 activation mediated the underlying cellular … Glioma is one of the most common
primary brain tumours … 1 was first revealed by the thymidine kinase (TK) mutated HSV-…

… kinase (HTK) is known to phosphorylate ganciclovir (GCV). … cancer gene therapy, especially
in brain tumors, and is under clinical investigation in the United States.' Retroviral mediated …

… that tumor rejection was mediated by a potent T-cell anti-tumor … HSV thymidine kinase
gene (HSV-TK) (76, 83) and treatment with ganciclovir, was partially attributable to an anti-tumor …

… -1 infection-mediated effects can be controlled with available HSV treatment options: acyclovir
and ganciclovir (… HSV-1-derived enzyme thymidine kinase (TK), causing cell death of HSV-…