GM3 Induces Terminal Differentiation of Leukemic Cells

CH Kim, CH Kim - GM3 Signaling, 2020 - Springer
… -induced differentiation of the human leukemic monocytic … lineage cells normally express
a lot of GM3 ganglioside. … during megakaryocytoid differentiation of PMA-induced K562 cells. …

Membrane Ganglioside-Specific Neuraminidase 3 (NEU3) Regulates GM3 Signaling

CH Kim, CH Kim - GM3 Signaling, 2020 - Springer
… ) synthase, blocks the megakaryocytic differentiation in K562 cellsGM3 is an inducing
modulator of megakaryocytoid cell differentiation, as confirmed by human erythroleukemic K562

3′-sialyllactose targets cell surface protein, SIGLEC-3, and induces megakaryocyte differentiation and apoptosis by lipid raft-dependent endocytosis

SH Ha, CH Kwak, JY Park, F Abekura, YC Lee… - Glycoconjugate …, 2020 - Springer
… to the ganglioside GM3 [9]. In the previous study [10, 11], it was shown that GM3 regulates
… To define the type of differentiated cell linage induced by 3SL, K562 cells were treated with …

[HTML][HTML] Induction of GD3/α1-adrenergic receptor/transglutaminase 2-mediated erythroid differentiation in chronic myelogenous leukemic K562 cells

SH Ha, SK Kang, H Choi, CH Kwak, F Abekura… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… ​4A), the expression of the ganglioside GD3 was clearly increased in K562 cells treated
with 10 μM epinephrine. However, the levels of GM3 and GD1a were diminished, as measured …

[HTML][HTML] Novel function of FAXDC2 in megakaryopoiesis

Q Jin, Y Ren, M Wang, PK Suraneni, D Li… - Blood cancer …, 2016 - nature.com
… (TPA)-induced megakaryocytic differentiation of K562 cells has … ), discovered in human
leukemia has been demonstrated to … through the increase of ganglioside GM3 resulting in the …

[图书][B] GM3 Signaling

CH Kim - 2020 - Springer
Ganglioside GM3 has advantages as a potential therapeutic agent. As … -like cell differentiation
can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines

[HTML][HTML] Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias

EJ Salustiano, KM da Costa, L Freire-de-Lima… - Journal of Biological …, 2020 - ASBMB
… alter these processes on human leukemias, the expression … a mix of GM1, GM2, and GM3
is indicated on the left of the … than on K562 suggest that this sphingolipid induces collateral …

[HTML][HTML] Serum GM3 (d18: 1-16: 0) and GM3 (d18: 1-24: 1) levels may be associated with lymphoma: An exploratory study with haematological diseases

M Nishikawa, M Kurano, T Nitta, H Kanoh, J Inokuchi… - Scientific Reports, 2019 - nature.com
… of GM3 is about 48% of total ganglioside content 11 . … the induction of differentiation in
several blood cell lines 5 and to determine the direction of differentiation in pluripotent K562 cells

[HTML][HTML] The role of sialyltransferases in gynecological malignant tumors

Y Zhang, R Wang, Y Feng, F Ma - Life Sciences, 2020 - Elsevier
… known as GM3 synthase, in leukemia cell lines HL-60 and k562, … may have a crucial rule in
inducing the expression of ST3Gal5 [24,… of gangliosides and STs in neuroepithelial cells were …

Regulatory mechanism for the human glioblastoma cell-specific expression of the human GD1c/GT1a/GQ1b synthase (hST8Sia V) gene

SY An, JW Lee, HD Kim, KS Kim, JH Cho, CH Kim… - Glycoconjugate …, 2023 - Springer
induces the increase in the ganglioside GQ1b production in human glioblastoma U87MG cells
was … biosynthesis, such as human GM3 synthase (hST3Gal V) and human GD3 synthase (…