Gap junctions and connexins in cancer formation, progression, and therapy

R Ruch - Cancers, 2020 - mdpi.com
gap junctional intercellular communication (GJIC) and gap junction proteins (connexins) in
the biology, … Gap junctions are a unique form of cellular junction in that they primarily serve as …

[HTML][HTML] IL-22 down-regulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis

J Liang, P Chen, C Li, D Li, J Wang, R Xue… - Journal of Investigative …, 2019 - Elsevier
Gap junctional intercellular communication (GJIC) is widely known for its involvement in
multiple biological and pathological processes such as growth-related events, cell differentiation…

Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation

C Li, L Shi, C Peng, G Yu, Y Zhang, Z Du - Chemico-biological interactions, 2021 - Elsevier
… To explore the mechanism of cardiovascular system injury induced by Pb exposure, we
hypothesized that gap junction intercellular communication and autophagy play an essential role …

Direct intercellular communications and cancer: a snapshot of the biological roles of connexins in prostate cancer

C Asencio-Barría, N Defamie, JC Sáez, M Mesnil… - Cancers, 2019 - mdpi.com
… of gap junction channels, … gap junctions between them. This idea was confirmed by
experiments showing that chemical re-induction of gap-junctional intercellular communication (GJIC) …

PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication

M Geletu, Z Taha, PT Gunning, L Raptis - Cancers, 2019 - mdpi.com
… cell adhesion proteins, was shown to be required for gap junction formation [28]. In addition,
… of PI3k and Stat3 upon the gap junctional communication apparatus. The results revealed …

GAP junctional communication in brain secondary organizers

C Bosone, A Andreu… - Development, growth & …, 2016 - Wiley Online Library
… , and intercellular communicationGap junction-mediated signaling is still a virgin field when
considering the largely unknown downstream signaling pathways of connexin biology. One …

Targeting gap junctional intercellular communication by hepatocarcinogenic compounds

K Leroy, A Pieters, A Tabernilla… - Journal of Toxicology …, 2020 - Taylor & Francis
… This review provides an overview of chemicals that compromise liver gap junctions, in
particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and …

Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells

TC Lin, KH Wang, KH Chuang… - Biotechnology and …, 2021 - Wiley Online Library
… be mediated by gap junctions [59]. Gap junctions are one type of junctional complex formed
by … GJIC is an important biological mechanism for the regulation of cellular proliferation, …

Gap junctional intercellular communication: A functional biomarker to assess adverse effects of toxicants and toxins, and health benefits of natural products

BL Upham, I Sovadinová, P Babica - JoVE (Journal of Visualized …, 2016 - jove.com
… bioassays is to take advantage of the biological phenomena that many, if not most, signal …
intercellular signaling systems through gap junction channels 4-8 . Although intercellular

Facets of communication: gap junction ultrastructure and function in cancer stem cells and tumor cells

A Beckmann, N Hainz, T Tschernig, C Meier - Cancers, 2019 - mdpi.com
… As the morphology and assembly of gap junction channels are crucial for their function in
intercellular communication, one focus of our review is to outline the data on gap junction