Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis

W Liao, V Pham, L Liu, M Riazifar, EJ Pone, SX Zhang… - Biomaterials, 2016 - Elsevier
… EAE mice. In vivo treatment with MSCs engineered with PSGL-1/SLeX/IL-10 in EAE mice
exhibited a … of MSC-based therapy for MS and other central nervous system (CNS) disorders. …

NLRP3 gain-of-function in CD4+ T lymphocytes ameliorates experimental autoimmune encephalomyelitis

TT Braga, WN Brandao, H Azevedo, FF Terra… - Clinical …, 2019 - portlandpress.com
… (MS), a disease that causes central nervous system (CNS) inflammation and demyelination.
… Spinal cord gene expression profiling of Rag-1−/− mice repopulated with naive T CD4 …

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

R Brambilla - Acta neuropathologica, 2019 - Springer
… Neuroinflammation is the coordinated response of the central nervous system (CNS) to …
Gene expression profiling of astrocytes isolated from EAE-induced mice untreated or treated with …

GM-CSF promotes chronic disability in experimental autoimmune encephalomyelitis by altering the composition of central nervous system–infiltrating cells, but is …

PC Duncker, JS Stoolman, AK Huber… - The Journal of …, 2018 - journals.aai.org
… of experimental autoimmune encephalomyelitis (EAE) and, ostensibly, in multiple sclerosis.
C57BL/6 mice … in the skin draining lymph nodes of primed mice, but it is not required for the …

Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis

RY Kim, D Mangu, AS Hoffman, R Kavosh, E Jung… - Brain, 2018 - academic.oup.com
nervous system of wild-type experimental autoimmune encephalomyelitis mice treated with
ERβ-ligand expressedGene expression profiles of CD11c+ microglia and CD11c+ dendritic …

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor

J Kaye, V Piryatinsky, T Birnberg… - Proceedings of the …, 2016 - National Acad Sciences
… To gain insight into laquinimod’s immunomodulatory mechanisms of action, spleen gene
expression profiles were compared between laquinimod- and vehicle-treated EAE mice, 6 d …

Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis

X Zhao, X Zhang, Y Lv, Y Xu, M Li, Q Pan, Y Chu… - Immunology …, 2016 - Elsevier
… MAT suppressed IL-33 and ST2 mRNA expression To determine mRNA expression of IL-33 …
cords of mice with EAE, and most, if not all, astrocytes expressed IL-33 in EAE lesions. IL-33 …

Nimodipine confers clinical improvement in two models of experimental autoimmune encephalomyelitis

J Ingwersen, L De Santi, B Wingerath… - Journal of …, 2018 - Wiley Online Library
… -mediated disorder of the central nervous system (CNS) affecting … changes in the expression
profile of these molecules … + SEM of gene expression in EAE mice (vehicle group n = 4; …

MicroRNA-150 targets PU. 1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis

L Shakerian, S Ghorbani, F Talebi… - Journal of …, 2018 - Elsevier
expression of PU.1 and its potentially targeting miRNAs in the central nervous system (CNS)
of mice with experimental … tissues reflects the average gene expression in different cell types…

Prevention and treatment of experimental autoimmune encephalomyelitis induced mice with 1, 25-dihydroxyvitamin D3

D Haghmorad, E Yazdanpanah… - Neurological …, 2019 - Taylor & Francis
… -type mice with EAE, the presence of Th17 cells have been shown in the central nervous
system … the relative quantity of mRNA expression compared with the β2 microglobulin reference …