[PDF][PDF] B7-1 and 4-1BB ligand expression on a myeloma cell line makes it possible to expand autologous tumor-specific cytotoxic T cells in vitro.

JFR Delteil, C Ferrand, B Klein - Citeseer
T lymphocytes were purified by depletion of non-T cells with … adoptively transferred
Melan-A-specific T cells in melanoma … Adoptive T cell therapy using antigen-specific CD8+ T cell

ImmunoMap: a bioinformatics tool for T-cell repertoire analysis

JW Sidhom, CA Bessell, JJ Havel, A Kosmides… - Cancer immunology …, 2018 - AACR
… Specificity of cytotoxic T lymphocytes (CTL) was monitored on day 7, by FACS analysis …
A, Naïve C57BL/6 animals were harvested for CD8+ T cells from spleens. CD8+ T cells were …

[HTML][HTML] Uncovering the tumor antigen landscape: what to know about the discovery process

S Feola, J Chiaro, B Martins, V Cerullo - Cancers, 2020 - mdpi.com
… of cancer-specific CD8+ T cells called cytotoxic T lymphocytes (CTLs) [… (CAR) T cells have
largely been adopted to target this class … purification can be used to identify spontaneous T cell

Modulating the glycolytic or Wnt-beta-catenin signaling pathway to generate EBV-specific human CD8+ cytotoxic T lymphocytes with stem cell memory and central …

I Weber - 2017 - openscience.ub.uni-mainz.de
generation and adoptive transfer of EBV-specific CD8+ cytotoxic T lymphocytes (CTL)
displaying stem cell … from EBV- donors were purified through MACS and primed with EBV-specific …

Cancer immunotherapy using tumor antigen-reactive T cells

BK Choi, SH Kim, YH Kim, BS Kwon - Immunotherapy, 2018 - Taylor & Francis
… tumor-specific T cells when adoptive T-cell therapy (ACT) was … for culturing tumor-specific
cytotoxic T cells (CTLs) [Citation7], … First-generation T-cell therapeutics use polyclonal T cells

Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack

F Mahmoud, B Shields, I Makhoul, N Avaritt… - Cancer biology & …, 2017 - Taylor & Francis
… Pharmacologic inhibition of the cytotoxic T lymphocyte antigen … from adoptive T cell therapy
with T-lymphocytes targeting Melan-… Melanosome preparations purified from melanoma cells

[HTML][HTML] Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

…, K Sachsenmeier, JD Clarke, B Linghu… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
… of tumor antigens enhancing cytotoxic T lymphocyte (CTL) … adapted for our studies: purified
human monocytes, obtained … product for identifying Melan-A-specific CD8 + T cells at the …

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

…, AD Tadmor, U Luxemburger, B Schrörs, T Omokoko… - Nature, 2017 - nature.com
… as checkpoint blockade and adoptive T cell transfer 6,7,22 . This … expansion of PBMCs,
purified CD8 + or CD4 + T cells or TILs. … cells were stained with 1 μg ml −1 of a Melan-A-specific

The Antitumor Effects of Vaccine-Activated CD8+ T Cells Associate with Weak TCR Signaling and Induction of Stem-Like Memory T Cells

…, Y Hong, L Huang, D Dong, J Xie, T Merchen… - Cancer immunology …, 2017 - AACR
… Two millions of the purified CD8 T cells were then restimulated … T cells, especially Tscm
and Tcm, are critical for generating … in CD45.1 mouse blood after adoptive cell transfer. C, The …

Activation of the transcription factor NFAT5 in the tumor microenvironment enforces CD8+ T cell exhaustion

…, M Charmoy, P Reichenbach, M Andreatta, T Wyss… - Nature …, 2023 - nature.com
… the generation of pathogenic CD4 + T helper type 17 cells 11 , … 1c) and in human
Melan-A-specific CD8 + T cells from tumor-… This discovery has implications for adoptive cell