A summary of the biological processes, disease-associated changes, and clinical applications of DNA methylation

GB Andersen, J Tost - DNA Methylation Protocols, 2018 - Springer
… that are part of the molecular machinery responsible for correct establishment and … DNA
methylation changes and genetic mutations co-occurring in the same tumors show different …

The diverse roles of DNA methylation in mammalian development and disease

MVC Greenberg, D Bourc'his - Nature reviews Molecular cell biology, 2019 - nature.com
… and re-establishment of DNA methylation in embryonic, germline … into DNA methylation
gained from studying genetic diseases. … of recruiting the DNA methylation machinery to ensure …

[HTML][HTML] DNA methylation in human diseases

S Younesian, MH Mohammadi, O Younesian… - Heliyon, 2024 - cell.com
… of DNA methylation machinery is a phenomenal intersection that each of its ways can reveal
the mysteries of various diseases, … of genetic alterations is notably low in many diseases. All …

DNA hypermethylation in disease: mechanisms and clinical relevance

M Ehrlich - Epigenetics, 2019 - Taylor & Francis
diseases, immunological diseases, atherosclerosis, and osteoporosis. In this review, I
discuss DNA hypermethylation in disease and … disruption of the epigenetic machinery [Citation56], …

DNA methylation in Parkinson's disease

U Wüllner, O Kaut, L deBoni, D Piston… - Journal of …, 2016 - Wiley Online Library
… the methylation machinery were identified in early, drug-naive sporadic PD patients (CBX5, …
, there is no doubt that in addition to genetic mutations, epigenetics and DNA methylation

[HTML][HTML] Understanding the relevance of DNA methylation changes in immune differentiation and disease

C Calle-Fabregat, O Morante-Palacios, E Ballestar - Genes, 2020 - mdpi.com
… Moreover, a subset of TFs that possess the ability to rearrange the epigenome (so-called
pioneer TFs) are able to interact with the epigenetic machinery, altering the DNA methylation

The interplay between DNA and histone methylation: molecular mechanisms and disease implications

Y Li, X Chen, C Lu - EMBO reports, 2021 - embopress.org
… A central question in the field is how DNA methylation machineries interact with other …
DNA-modifying enzymes implicated in human diseases (Hansen et al, 1999). Genetic alterations in …

Principles of DNA methylation and their implications for biology and medicine

Y Dor, H Cedar - The Lancet, 2018 - thelancet.com
DNA methylation could provide a valuable tool for monitoring tissue dynamics and diagnosing
multiple diseases. … them and then recruited the methylation machinery. This secondary …

[HTML][HTML] Genetic impacts on DNA methylation: research findings and future perspectives

S Villicaña, JT Bell - Genome biology, 2021 - Springer
disease onset and progression. In this review, we summarize recent milestones in characterizing
the human genetic basis of DNA methylation … , or even machine learning approaches …

[HTML][HTML] The DNA methylation in neurological diseases

S Younesian, AM Yousefi, M Momeny, SH Ghaffari… - Cells, 2022 - mdpi.com
… of both genetic disorders and epigenetic alterations, … changes in DNA methylation machinery
can reduce the expression of Reelin and GAD67, encoding by RELN and GAD1 genes, …