… Cannabinoid receptors CB1 and CB2 are expressed in bone and regulate … between the
effect of CB1 and CB2 activation reported using genetically modified animal models. Studies on …

… receptors type 1 (CB1) and type 2 (CB2) (3); transient … no changes in biomechanical
characteristics of femoral bones of … , can influence the effects of cannabinoid receptor signaling on …

… of Cannabis sativa has been implicated in changes in bone … precursor cells by suppressing
cannabinoid receptor type 2. … We observed that genetic inactivation of CB1 receptors in …

… on the action of the cannabinoid receptor ligands in skeleton … receptor type 2 (CB2R), which
were isolated and cloned only … in bone by modifying OB and OC differentiation and actions. …

… bone formation and bone mass in aged mice, suggesting that constitutive genetic inactivation
of sympathetic CB1 receptor … in DBH-CB1-KO mice (A), with no significant changes in the …

… and genetic modulation of Cnr2 affects bone mass … Cnr2 deficiency in adult mice results
in high peak bone mass … bone that progressively alters bone cell activity and turnover …

… that cannabinoid receptor agonists stimulate bone resorption and … Mice with deficiency of
the type 2 cannabinoid receptor (… studies are influenced by age, sex, and genetic background. …

… bone metabolism; however, little is known as to how CB1 and … will also determine changes
in expression of genes and what … The type 2 cannabinoid receptor regulates bone mass and …

… in skeletal biology via the cannabinoid receptors CB1, CB2 and … on a CD1 background
displayed a high bone mass (HBM) … Cannabinoid receptor type 2 gene is associated with human …

… are significantly modulated by cannabinoid receptors in oral … and/or the construct used
for gene mutation with an effecting … perception of potential changes aroused by CB1 or CB2 …