… are dependent on the genes involved and environmental factors. … Genetic testing for these
disorders is now available, … the genetic and clinical features of surfactant protein dysfunction …

… with surfactant proteins B and C to form surfactant. The … genes that encode key components
of pulmonary surfactant include surfactant protein B (SP-B, SFTPB gene), surfactant protein …

… This article describes the genetic origin of surfactant-related lung … carriers of germline
mutations in surfactant-related genes. … Furthermore, surfactant proteins play an important role in …

… in surfactant homeostasis. [7,8] Additionally, pathogenic variants in genes encoding surfactant
protein B … Although these variants encoding surfactant protein genes may be important risk …

… Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to …
Conclusion: This review article seeks to provide an overview of surfactant protein disorders in the …

… In addition to surfactant proteins, surfactant lipids are critical for surface activity and stability
… transporter essential for organelle biogenesis, surfactant protein-phospholipid assembly, and …

… Besides the genetically defined surfactant dysfunction disorders, most entities pathologically
involve the alveolar surfactant region, possibly affecting the surfactant proteins SP-B and SP…

… Surfactant proteins B and C contribute to the surface tension-… transplanted for genetic disorders
of surfactant metabolism, we … likely to be transplanted for surfactant protein B deficiency, …

… , respiratory disorders as pediatric acute respiratory distress syndrome or interstitial lung
disease, are commonly associated with genetic mutations involving surfactant proteins (mainly …

… at electron microscopy may suggest a disorder in surfactant metabolism [26, 27]. (Fig. 1). …
Our study shows that candidate variants in surfactant protein genes were identified also in …