… ) Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am
… Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice. Am J …

… , each element of the neural tube closure sequence has its own distinct genetic requirements
[50]. Similarly, a distinct set of genes is required for development of the secondary neural …

… The purpose of this review is to outline the evolution of genetic studies of NTDs, from studies
of familial … Strategies for addressing gaps in NTD genetic research are also explored. …

… Neural tube defects arise early in human embryogenesis when the neural tube, the precursor
to the brain and spinal cord, fails to properly close during neurulation. Failure to complete …

… agents interacting with inherited susceptibility genes are the major contributing factors.
Neural tube defects (NTDs) are among the most prevalent human birth defects and as such, …

… necessary to discover a given numbers of genes as recurrently mutated, assuming that
there are 100 ‘discoverable’ genes for haploinsufficient neural tube defects (NTDs) in humans. …

… with neural tube defects which identify the genes needed for embryonic neural tube closure
(… a mutation does not have to mean a certain development of NTDs because, in most cases, …

… has been reported for neural tube defects, possibly because of a sex-related genetic or
epigenetic effect. Despite the decades long attempts to elucidate genetic factors causative of …

… infants with neural tube defects (NTDs) associated with genes … the genetic variants of the
fourteen special reported genes, … associated abnormalities rate (AAR) within the developmental …

… of genetic studies on humans and animals demonstrated the role of aberrant genes in the
developmental risk of neural tube defects … occur during embryonic development. Other studies …