… in cell migration, PIPKIγ knockout mice are lethal beyond embryonic day 11.5 due to defects
… by PIPKIγ or other PIPKIs could be converted to PI3,4,5P 3 by the action of class I PI3Ks and …

… and can bind various effector proteins. Well-characterized RAS effectors include RAF proteins…
Focused CRISPR screens identify genes that confer SHP099 resistance in multiple cancer …

… understand the functions of some effectors, our knowledge of L… Yet, these screens identified
relatively few host factors that … identified as protective hits at FDR ≤ 10%, including actin …

… its ability to bind Golgi PI4P and the actin network. GOLPH3 contains a basic region that …
the Rab11 effector FIP3. The interaction of PI4KB with Rab11 does not appear to regulate either …

… We thus performed genome-wide screens to identify genes that are closely associated
with Rho5 and are likely involved in oxidant-induced cell death. Here, we report that several …

The process of cytokinesis ultimately results in the partitioning of a mother cell into two
daughter cells. Cytokinesis is initiated through the formation of an actomyosin ring at the …

… on the known PI3,5P 2 effector protein Atg18. Our work thus … We asked whether lethality
between the PI3,5P 2 deficient … change in response to Kin4 action. Normally, Bfa1 localizes …

… A common feature missing from effectors that downregulate PI(4,5)P 2 synthesis is the
identity of sensors that detect changing PI(4,5)P 2 levels and modulate these effectors …

… regulatory mechanisms of this pathway to identify new … effectors YAP1/TAZ 1,2 . Mitogen
activated protein kinases (MAP4Ks) were also discovered as additional core components acting …

… genomic integrity is posed by the absence of comprehensive characterization of their downstream
target proteins. To identify the potential effectors … ), followed by large-scale proteomics …