… and regulate the activity of a large number of effector proteins… In summary, our screen identified
several components of the … a cell-autonomous manner and those likely acting via cell-cell …

… ), and are degraded by the action of phosphoinositide phosphatases (up to 35 … is regulated
by inhibitory autophosphorylation 24 . Loss of PIKfyve protein leads to embryonic lethality in …

… of effectors into the host cytosol ....... 4 Host-targeted genetic … A systematic RNAi screen
identifies a critical role for … we removed genes with lethal single-genedeletion phenotypes as their …

… in the cell is generated by the Type I kinases, here we are focusing on the small but significant
pool of PI-4,5-P 2 that is created by the action of the Type II kinases, which to date is under …

… DNA damage response that provides new targets for synthetic lethality of tumors. … regulate
PIPKIα but serves as a downstream effector of PIPKIα through nuclear PI(4,5)P 2 in regulating …

… cell and a depleted region of cortical actin which allows an unobstructed area in preparation
… of effector machinery [101]. Furthermore, a genome wide regulatory network identified …

… At the Golgi apparatus, PI4P binds effector proteins and regulates the anterograde transport
from … However, it is assumed that it could be through the regulation of actin reorganization. …

… of PPIns interactor and effector proteins in the nucleus have … While knockouts of this enzyme
in mice lead to neonatal lethality … regulate histone H3K4me3 may be a conserved action in …

… its pathogenesis, I developed and carried out a genome-wide CRISPR/Cas9 knockout
screen … greater detail the roles of three of the major identified hits, using a further panel of …

… This result was linked to two downstream effectors of … or genomic scale (58). Here, targeting
the kinome provided an insightful view of the RABV infectious cycle, identifying new key host …