… to the recruitment of distinct effector proteins that can then perform downstream functions. …
acid changes responsible for the hyperactivity of the Vps34 mutants identified in our screen. …

… Homozygous Atg9 B5 and hemizygous Atg9 B5 /Df(2 R)ED2487 flies are morphologically
normal but semi-lethal that could be rescued by our genomic promoter-driven transgenes, in …

… lipid signaling molecules that govern key cellular processes including … to regulate cell
growth, metabolism, survival, and proliferation [1, 2]. Phosphoinositide levels are tightly regulated …

… We found that PtdIns4,5P2 depletion significantly reduced … Our findings provide new
mechanistic information about … of PtdIns4,5P2 is as a positive allosteric effector. This scenario …

… were marked by actin patches, enriched in PtdIns4,5P 2 and … overproduction of the PtdIns4,5P
2 effector Slm1, an adaptor … However, PI3K-activated Akt suppressed the lethality derived …

… bacterial effectors, plants deploy a second layer of defence that is called effector triggered
… All values were normalized to an internal actin control. Consistent with the results from the …

… of effectors. For instance, PtdIns(4,5)P 2 recruits clathrin adaptors or proteins that control the
actin … Homozygous murine Pik3c2a deletion is embryonic lethal at E10.5 due to impaired …

… Phosphatidylinositol-4,5-bisphosphate (PI(4,5)P 2 ) plays numerous roles in cellular regulation.
It mediates actin remodeling at the plasma membrane, modulates vesicle trafficking, and …

… by FAPP1 KD is mediated by the PI4P effector GOLPH3 129 3.9 FAPP1 KD does not affect
… Actin (Sac)1 (Novick, Osmond and Botstein, 1989). A concomitant genetic screen identified …

… the functions and regulatory mechanisms of this pathway to identify new therapeutic targets.
… Yorkie (yki), the Hippo pathway’s leading functional effector, was later identified in a screen …