… in neurodegeneration and perinatal lethality in mice. The … regulated by PI(3,5)P 2 , as
PI(3,5)P 2 protein effectors have … action of VPS34 and PIKfyve to regulate endocytic recycling. …

… Comparing the interactomes of WT and constitutively active G12D mutant of RAS isoforms,
we identified several potential previously unknown effector proteins of RAS, one of which was …

… new organisms formed by normal cells that have undergone gene mutations due to the action
… the PI3K/AKT pathway in turn activates downstream effectors such as cyclin A2, cyclin D1, …

… Our screen identified synthetic growth defect between FKS1 … of the actin network, could
permit a joint regulation of these two … of unique sets of effectors. The phosphatidylinositol 3-…

… Likewise, the role of PtdIns4,5P2 in serving as a positive allosteric effector of TORC2 is …
Genome-wide lethality screen identifies new PI4,5P 2 effectors that regulate the actin cytoskeleton…

… Reduced disengagement of the PI(4,5)P 2 effector clathrin was … KIF5B (31) and the actin
nucleation promoting factor WHAMM (… of the Inpp5k gene in mice is embryonically lethal (40), so …

… effector landscape of Arf proteins, especially for the less-studied members, revealing new …
There is other evidence showing that Arf proteins directly regulate actin assembly. The …

… -GTPase family that controls actin cytoskeleton dynamics, transcriptional regulation, and cell
cycle … OCRL is an effector of Rab8 and Rab5 and depletion of OCRL leads to the reduced …

… of PIP function and regulation, delineate the disorders associated with mutations in genes
that modulate or utilize PIPs, and discuss what is understood about gene function and disease …

… We previously used proteome-wide mass spectrometry to identify proteins that are … by
target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2. …