… -regulated small GTPase activation or deactivation. (f) Schematic representation of effector
… The notion that phosphoinositides might regulate actin dynamics in the late secretory …

… A muscle-targeted genetic screen identified specific phosphoinositide lipid regulators … major
phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila. J Biol …

… new relevant aspects that are discussed in detail, including the effector-effector suppression
screen (to identify … The array identified 13 genes that shared a synthetic lethality partner with …

… actin formation in lymphocytes 68, we are investigating a role for SHIP Tyr944 in regulating
actin … and controlling macrophage differentiation into regulatory and effector types 118. SHIP …

… bacterial effectors are lethal to yeast upon expression, results obtained from these screens
… Accordingly, we have recently used this system to identify and begin the characterization of …

… regulates organization of the actin cytoskeleton [5,6], as previously shown for yeast TORC2
[7,8]. Here we review the structure, effectors, localization, and regulation of … mammalian lethal …

… to play a key regulatory role for a wide range of cellular … of effector proteins related to lipid
biosynthesis and transport. … control many processes including vesicular trafficking, actin …

… Collectively, these distal effectors of TORC2 contribute to the maintenance of a particular
property of … Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin …

… Our screen identified synthetic growth defect between FKS1 … of the actin network could permit
a joint regulation of these two … recruitment/activation of unique sets of effectors. The PI(3)P …

… general mechanism whereby individual Rho effectors drive specific actin- based structures.
… An independent proteomic screen identifying Rho GTPase family protein interactors showed …