… effectors have been identified, but the mechanisms by which the small GTPase switches
effectors, or how multiple effectors … and 61 suggests that such mutants would be lethal or sterile. …

… to identify potential targetable effectors. Recently, the mechanistic target of rapamycin complex
2 (mTORC2) was identified as an evolutionarily conserved Ras effector… control of the actin …

… In cells, membrane domains regulate membrane dynamics and biochemical and signaling
pathways. We and others identified a highly conserved family of sterol transport proteins (Ltc/…

… Our screen identified synthetic growth defect between FKS1 … of the actin network, could
permit a joint regulation of these two … of unique sets of effectors. The phosphatidylinositol 3-…

… an effector of the type III secretion system that acts on plasma membrane lipids, causing
membrane rupture and host cell necrosis. Here, we use a genome-wide screen … high fatality rate …

… Nonetheless, at the outset of this study the mechanism of action of PI3K-C2β in regulation of
… to various downstream effector proteins via distinct lipid-binding domains and control their …

… into four subfamilies (I-IV) were identified [[28], [29], [30]](Fig. 1); They have played crucial
roles in deciphering the mechanistic principles of ORP action (see Section 8). In humans and …

… PI(3)P, which further recruits its effector proteins, DFCP1 to omegasomes and WIPI2 and
WIPI4 to … A genome-wide CRISPR screen identified TMEM41B and VMP1 as host factors for …

… regulated by PIKI-1, VPS-34, and MTM-1 [16]. MTM-1 is recruited to the surface of extending
pseudopods as an effector of … that rab-35 defines a third pathway by acting in parallel to both …

… of the cell membranes, interact with numerous effector proteins and were shown to serve as
… The role of phosphoinositide-regulated actin reorganization in chemotaxis and cell migration…