Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis

A Del Real, FM Pérez-Campo, AF Fernández… - Epigenetics, 2017 - Taylor & Francis
… of hMSCs in the pathogenesis of osteoporosis is still unclear. … to skeletal development are
differentially methylated in bonedifferentially methylated regions in comparison with hMSCs …

Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women

S Reppe, TG Lien, YH Hsu, VT Gautvik, OK Olstad… - Epigenetics, 2017 - Taylor & Francis
osteoporosis, we combined transcript profiling with DNA … findings among the 63 differentially
methylated CpGs (using FDR = … muscle reveals both direct and indirect regulation of muscle …

Alterations in DNA methylation profiles in cancellous bone of postmenopausal women with osteoporosis

Y Zhou, L Yang, H Wang, X Chen, W Jiang… - FEBS Open …, 2020 - Wiley Online Library
methylation microarray analysis of the hip cancellous bone of patients with osteoarthritis
revealed differential methylation. … bone in bone development, we examined genome-wide DNA …

Comparative profiles of DNA methylation and differential gene expression in osteocytic areas from aged and young mice

Y Wei, J Fu, W Wu, J Wu - Cell Biochemistry and Function, 2020 - Wiley Online Library
… factors in age-related bone loss, either together or individually. … the differentially methylated
regions (DMRs), differentially … studies have revealed that SCFAs can improve the bone loss

[HTML][HTML] Relationship between osteoporosis and osteoarthritis based on DNA methylation

Y Li, B Xie, Z Jiang, B Yuan - International journal of clinical and …, 2019 - ncbi.nlm.nih.gov
… [23] studied the genome-wide methylation profile of the bones in patients with hip … genome-wide
methylation analysis of bone samples revealed the regions with differential methylation

DNA methylation signatures of bone metabolism in osteoporosis and osteoarthritis aging-related diseases: an updated review

VV Visconti, I Cariati, S Fittipaldi, R Iundusi… - International Journal of …, 2021 - mdpi.com
… in bone biopsies from postmenopausal OP women, revealingProfiling analysis identified
7316 differentially methylated … However, these differentially methylated regions of the genome

[HTML][HTML] Genome-wide DNA methylation analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells

Y Cao, H Yang, L Jin, J Du, Z Fan - Stem cells international, 2018 - hindawi.com
… Our results also revealed that, along with the induced … the genes related to the differentially
methylated regions (DMGs) by … during local irradiation-induced bone loss in rats,” Scientific …

Genome-wide identification of m6A-associated SNPs as potential functional variants for bone mineral density

XB Mo, YH Zhang, SF Lei - Osteoporosis International, 2018 - Springer
Genome-wide mRNA expression was profiled using mRNA Human … This region shows
very high conservation, transcription level, and DNaseI hypersensitivity. The tracks sequentially …

Identification of an epigenetic signature of osteoporosis in blood DNA of postmenopausal women

D Cheishvili, S Parashar, N Mahmood… - Journal of Bone and …, 2018 - academic.oup.com
methylation profile from controls increases with advanced stages of OP. We next overlapped
differentially methylated … Epigenome‐wide methylation analysis revealed 1233 significantly …

Genomewide DNA methylation profile analysis in thoracic ossification of the ligamentum flavum

T Fan, X Meng, C Sun, X Yang, G Chen… - Journal of Cellular …, 2020 - Wiley Online Library
… shortlisted the differentially methylated GO terms functionally related to bone development,
… shown to have distinct epigenomic profiles, and the Venn diagram revealed 65 significantly …