Identification of ferroptosis-associated biomarkers for the potential diagnosis and treatment of postmenopausal osteoporosis

Y Hu, J Han, S Ding, S Liu, H Wang - Frontiers in Endocrinology, 2022 - frontiersin.org
… To prevent bone loss, a proactive approach is recommended … We then curated the expression
profiles of the DEFAGs for … OP can be revealed through the study of OP candidate gene

Unraveling Key m6A Modification Regulators Signatures in Postmenopausal Osteoporosis through Bioinformatics and Experimental Verification

Z Feng, H Xiao, X Wang, Y Niu, D Zhao… - Orthopaedic …, 2024 - Wiley Online Library
osteoporosis (PMOP) patients and femoral bone tissue from … attributes of OP-BMSCs, our
study seeks to reveal innovative … two OP-related gene expression profiles (GSE35956 and …

The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding

Y Wang, X Huang, Q Zhang, C Cheng, Z Qin… - Journal of Molecular …, 2024 - Springer
… evaluation of osteoporosis is mainly based on bone mineral density (… Considering that CpG
island may be differentially methylated in … Mechanistic studies have revealed that E2F6 could …

Epigenetic mechanisms in osteoporosis

B Ostanek, T Kranjc, N Lovšin, J Zupan… - Epigenetics of aging and …, 2018 - Elsevier
… ) on genomic scale or individual DNA regions or miRNA … , a genome-wide methylation
profiling of bone tissue samples … the promoter regions of ∼1500 differentially methylated genes …

[HTML][HTML] Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice

M Bourgery, E Ekholm, K Fagerlund, A Hiltunen… - Bone Reports, 2021 - Elsevier
… Increasing evidence shows that small noncoding RNAs are … fracture healing, genome
wide expression profiles of tiRNAs, … and, compared to intact bone and articular cartilage at 2 …

DNA methylation and noncoding RNA in OA: Recent findings and methodological advances

V Izda, J Martin, C Sturdy, MA Jeffries - Osteoarthritis and cartilage open, 2021 - Elsevier
… more differential methylation in subchondral bone compared … to late-stage bone and cartilage
groups revealed 111 shared … other underlying medical conditions, such as osteoporosis). …

[HTML][HTML] DNA methylation in osteoarthritis: current status and therapeutic implications

A Miranda-Duarte - The open rheumatology journal, 2018 - ncbi.nlm.nih.gov
methylation profiles; 3) Differentially Methylated Regions (… patients with Osteoporosis (OP),
with an inverse methylation … pathways (ie., skeletal system morphogenesis) and HOX genes […

The role of CD40 and CD40L in bone mineral density and in osteoporosis risk: A genetic and functional study

L Panach, B Pineda, D Mifsut, JJ Tarín, A Cano… - Bone, 2016 - Elsevier
… We describe a differential methylation of CpGs in the CD40 … data are revealing that the
CD40/CD40L system is involved in bone … different methylation profiles in the CD40 gene promoter …

Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells

W Sun, Y Song, K Xia, L Yu, X Huang, Z Zhao… - Stem Cell Research & …, 2021 - Springer
… of bone biology, m 6 A modification plays critical roles in bone development as well as bone
diseases such as osteoporosis… these differentially methylated and regulated genes revealed

In-depth exploration of the shared genetic signature and molecular mechanisms between end-stage renal disease and osteoporosis

W Lou, W Li, M Yang, C Yuan, R Jing, S Chen… - Frontiers in …, 2023 - frontiersin.org
… explore the common genetic profile and potential molecular … high bone turnover disease, as
they both reduce bone turnover… Our work shows that hub genes can be used as indicators of …