Identification of differentially methylated regions in new genes associated with knee osteoarthritis

CA Bonin, EA Lewallen, S Baheti, EW Bradley… - Gene, 2016 - Elsevier
… have revealed significant differences in DNA methylation between OA and non-OA bone
This work provides an assessment of differences in methylation profile between visually …

Use of integrative epigenetic and mRNA expression analyses to identify significantly changed genes and functional pathways in osteoarthritic cartilage

A He, Y Ning, Y Wen, Y Cai, K Xu, J Han… - Bone & joint …, 2018 - boneandjoint.org.uk
differentially methylated genes, including 678 methylated and 587 demethylated genes.
Integrating the DNA methylation of mRNA expression profiles … findings, and reveal the potential …

Epigenetic regulation of bone remodeling and its impacts in osteoporosis

C Ghayor, FE Weber - International journal of molecular sciences, 2016 - mdpi.com
… , methylation, phosphorylation and ubiquitylation modifications, recent studies have revealed
other … Early studies revealed the association of hyperacetylated histones, which results in …

Transcriptional profiling of human femoral mesenchymal stem cells in osteoporosis and its association with adipogenesis

YJ Choi, I Song, Y Jin, HS Jin, HM Ji, SY Jeong… - Gene, 2017 - Elsevier
… human MSCs from the bone marrow of typical severe osteoporosis patients and controls …
the NR4A family and bone metabolism. Our IPAs also revealed a possible relationship between …

Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis

P Yi, X Xu, J Yao, B Qiu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
… The incidence of differential methylation varied in subregions of the genome and the … bone
marrow mesenchymal stem cells resulted in the impediment of postmenopausal osteoporosis (…

Comprehensive analysis of epigenetics mechanisms in osteoporosis

Y Chen, Y Sun, X Xue, H Ma - Frontiers in Genetics, 2023 - frontiersin.org
Osteoporosis is a metabolic disorder that bones become more … rate of bone formation is not
equal to the rate of bone loss, it … This research revealed a notable augmentation in the SOST …

Novel regional age-associated DNA methylation changes within human common disease-associated loci

CG Bell, Y Xia, W Yuan, F Gao, K Ward, L Roos… - Genome biology, 2016 - Springer
genome-wide DNA methylomes aged 19–82 years, we identify 71 age-associated differentially
methylated regions … regards to age-related bone loss, shows methylation change in those …

[HTML][HTML] Hypomethylation of the RUNX2 Gene Is a New Potential Biomarker of Primary Osteoporosis in Men and Women

B Yalaev, A Tyurin, K Akhiiarova… - International Journal of …, 2024 - mdpi.com
… Research shows that the expression of the RUNX2 gene is … postmenopausal osteoporosis
patients and affect bone tissue … differentially methylated region of RUNX2 and localized in this …

Identification of biomarkers associated with diagnosis of postmenopausal osteoporosis patients based on bioinformatics and machine learning

X Huang, J Ma, Y Wei, H Chen, W Chu - Frontiers in Genetics, 2023 - frontiersin.org
bone loss and an increased risk of fracture, a systemic bone … analysis revealed ACACB and
WWP1 differential expression … RBCK1 were identified as differentially methylated genes. All …

Assessment of DNA methylation patterns in the bone and cartilage of a nonhuman primate model of osteoarthritis

G Housman, LM Havill, EE Quillen, AG Comuzzie… - Cartilage, 2019 - journals.sagepub.com
… one sample that is either from healthy bone, healthy cartilage, OA bone, or OA cartilage. In
… of Differential Methylation To identify sites that were significantly differentially methylated