From genome-wide association study to phenome-wide association study: new paradigms in obesity research

YP Zhang, YY Zhang, DD Duan - Progress in molecular biology and …, 2016 - Elsevier
… variants identified in the genome-wide association studies (… -wide association study (PheWAS).
We will discuss the … to a significant increase in the morbidity and mortality of many chronic …

Genome-wide association study of morbid obesity in Han Chinese

KM Chiang, HC Chang, HC Yang, CH Chen, HH Chen… - BMC genetics, 2019 - Springer
obesity gene, FTO, was first identified in … studies indicated the association of this SNP
with neurological disorders such as attention deficit hyperactivity disorder (ADHD), and early-onset

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

JP Bradfield, S Vogelezang, JF Felix… - Human molecular …, 2019 - academic.oup.com
adult obesity-related traits, less is known about the genetics specific for early-onset obesity
and with only a few studies … us to both identify an additional pediatric obesity locus and further …

A candidate-gene approach identifies novel associations between common variants in/near syndromic obesity genes and BMI in pediatric and adult European …

DX Wang, Y Kaur, A Alyass, D Meyre - Diabetes, 2019 - Am Diabetes Assoc
… European BMI genome-wide association studies conducted by … in several cases of early
onset obesity without additional … role in obesity (ie, clinically evident cases of morbid obesity with …

Rare variant analysis of obesity-associated genes in young adults with severe obesity from a consanguineous population of Pakistan

S Saeed, QM Janjua, A Haseeb, R Khanam… - Diabetes, 2022 - Am Diabetes Assoc
obesity-associated traits by genome-wide association studies. … , large genome-wide association
studies (GWAS) identified … ≥35 kg/m 2 , early-onset obesity, and hyperphagia within the …

Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants

C Serra-Juhé, GA Martos-Moreno, F Bou de Pieri… - PLoS …, 2017 - journals.plos.org
… in more than 100 loci have been identified by Genome Wide Association Studies (GWAS), …
Genome-wide association study for early-onset and morbid adult obesity identifies three new

Evaluation of the genetic association between adult obesity and neuropsychiatric disease

P Stahel, A Nahmias, SK Sud, SJ Lee, A Pucci… - Diabetes, 2019 - Am Diabetes Assoc
… been identified predominantly in patients with early-onset and/or … More recent genome-wide
association studies have … NPD and obesity, with Mendelian randomization studies indicating …

Rare variants in genes linked to appetite control and hypothalamic development in early-onset severe obesity

P Loid, T Mustila, RE Mäkitie, H Viljakainen… - Frontiers in …, 2020 - frontiersin.org
… , including twin studies, genome-wide association studies (GWASs), … early-onset obesity are
likely to be related to the identified … A linkage analysis in French families with morbid obesity

Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants

B Namjou, IB Stanaway, T Lingren, FD Mentch… - … Journal of Obesity, 2021 - nature.com
early onset obesity and hyperphagia [6]. MC4R-associated … surrounding MC4R and
genome-wide association of BMI, … codes related to overweight, obesity, and morbid obesity (best …

Identification of novel genetic variants for type 2 diabetes, childhood obesity, and their pleiotropic loci

CP Zeng, X Lin, C Peng, L Zhou, HM You… - Journal of human …, 2019 - nature.com
… Here, we aim to identify novel SNPs associated with T2D and childhood obesity (CO), …
Genome-wide association studies (GWASs) have revealed a number of single-nucleotide …