Poly (A) code analyses reveal key determinants for tissue-specific mRNA alternative polyadenylation

L Weng, Y Li, X Xie, Y Shi - RNA, 2016 - rnajournal.cshlp.org
… testing, and used the remaining PASs with 10-fold cross validation to learn the optimal hyper
parameters for each prediction model. We used both accuracy and the area under the ROC …

Genome-and tissue-wide analysis of alternative polyadenylation events using clustering and feature learning methods

P Yılmazer - 2019 - open.metu.edu.tr
… of tissue-specific gene expressions and differences across tissues and cell types. Our
genome-wide … to our research, investigate alternative polyadenylation in tissue specific manner in …

A Tissue-Specific Landscape of Alternative Polyadenylation, lncRNAs, TFs, and Gene Co-expression Networks in Liriodendron chinense

Z Tu, Y Shen, S Wen, H Liu, L Wei, H Li - Frontiers in Plant Science, 2021 - frontiersin.org
… These findings provide a genome-wide landscape of lncRNAs in L. chinense. … This study
also identified two hub TFs and 18 tissue-specific hub genes with important research value that …

A survey on methods for predicting polyadenylation sites from DNA sequences, bulk RNA-seq, and single-cell RNA-seq

W Ye, Q Lian, C Ye, X Wu - Genomics, Proteomics & …, 2023 - academic.oup.com
Identification of poly(A) sites (pAs) on a genome-wide scale … of a single gene, termed
alternative polyadenylation (APA), can … for pA prediction, including non-3′ UTR, tissue-specific, …

[图书][B] Inference of Computational Models of Alternative Polyadenylation and Splicing

MKK Leung - 2018 - search.proquest.com
… predict tissue-specific polyadenylation and splicing patterns. … computational models are
trained on genome-wide patterns … data to infer accurate predictive models of complex outcomes. …

Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes

Z Xue, RL Warren, EA Gibb, D MacMillan, J Wong… - BMC genomics, 2018 - Springer
… We acknowledge their limitation in showing genome-wide tumor-specific APA regulations.
Still, the genes inspected in our study reveal that APA regulation in cancer is more complex …

Inference of the human polyadenylation code

MKK Leung, A Delong, BJ Frey - Bioinformatics, 2018 - academic.oup.com
model that can predict the tissue-specific strength of a … that can predict alternative
polyadenylation patterns from transcript … In this work, we apply the predictive model to multiple …

A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data

M Chen, G Ji, H Fu, Q Lin, C Ye, W Ye… - Briefings in …, 2020 - academic.oup.com
… capture 3′ ends of mRNAs have been developed for genome-wide profiling of poly(A) sites,
such … APA has emerged as a widespread mechanism highly modulated in tissue-specific or …

DeepPASTA: deep neural network based polyadenylation site analysis

A Arefeen, X Xiao, T Jiang - Bioinformatics, 2019 - academic.oup.com
Alternative polyadenylation (polyA) sites near the 3 ′ end of a … As alternative polyA sites
are common in mammalian genes, … the tissue-specific polyA site prediction model with the non-…

A deep neural network for predicting and engineering alternative polyadenylation

N Bogard, J Linder, AB Rosenberg, G Seelig - Cell, 2019 - cell.com
Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …