Recent advances in the epigenetics of bone metabolism

Y Xu, J Ma, G Xu, D Ma - Journal of bone and mineral metabolism, 2021 - Springer
osteoporosis genome-wide association studies and multi-omics technologies have revealed
… markedly in BMD, and the differentially methylated CpG sites most significantly associated …

[HTML][HTML] Multiple targets identified with genome wide profiling of small RNA and mRNA expression are linked to fracture healing in mice

M Bourgery, E Ekholm, K Fagerlund, A Hiltunen… - Bone Reports, 2021 - Elsevier
… Increasing evidence shows that small noncoding RNAs are … fracture healing, genome
wide expression profiles of tiRNAs, … and, compared to intact bone and articular cartilage at 2 …

[PDF][PDF] The relationship of promoter methylation of calcium voltage-gated channel alpha 1 and interleukin-16 to primary osteoarthritis

L Kehribar, Z Betul Celik… - Eur. Rev. Med …, 2023 - europeanreview.org
… patients have differentially methylated regions in their genome. Fernandez et … Genomewide
profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. …

Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci

L Mikkola, S Holopainen, T Pessa-Morikawa… - BMC genomics, 2019 - Springer
… were noggin (NOG), a bone and joint developmental gene on … We report three loci with
genome-wide significance and two … as it has been shown to be differentially methylated in OA [55] …

Epigenetics of bone diseases

L Michou - Joint Bone Spine, 2018 - Elsevier
… A genome-wide methylation study was conducted on mesenchymal stem cells … osteoarthritis
[20]. Cells from the group with osteoporosis exhibited accelerated age-related methylation

Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

J Steinberg, GRS Ritchie, TI Roumeliotis… - bioRxiv, 2016 - biorxiv.org
… progression, combining genome-wide DNA methylation, RNA … We also identified 271
differentially methylated regions (… to be differentially transcribed in osteoarthritic bone, consistent …

Intraspecific and interspecific investigations of skeletal DNA methylation and femur morphology in primates

G Housman, EE Quillen… - American journal of …, 2020 - Wiley Online Library
skeletal pathologies and disorders, such as osteoporosisgenome-wide and gene-specific
DNA methylation in primate … were significantly differentially methylated across comparative …

[HTML][HTML] DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation

R Gómez, MJ Barter, A Alonso-Pérez, AJ Skelton… - Biological …, 2023 - SciELO Chile
… our osteoblastogenesis differentially methylated regions with … osteoarthritis where osteoporotic
and sclerotic bone regions … seq information about the genome-wide binding sites for 161 …

Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus

S Hackinger, K Trajanoska… - Human molecular …, 2017 - academic.oup.com
… have been carried out by the Genetic Factors for Osteoporosis (GEFOS) consortium: a
large-… on a genome-wide level. Here, we present results from the first genome-wide analysis …

Epigenetic mechanisms in bone biology and osteoporosis: can they drive therapeutic choices?

F Marini, L Cianferotti, ML Brandi - International journal of molecular …, 2016 - mdpi.com
… A genome-wide study evaluated the DNA methylation profile, at the genome level (…
superfamily genes, differentially methylated between osteoporosis and osteoarthritis, include genes …