… methylation reprogramming in pig germ cells follows the general dynamics shown in mice
… that takes place at these stages is a complex process, triggered by the base excision repair …

… involves attenuation of the MAPK (ERK) pathway and both de novo and maintenance DNA
… To examine epigenetic reprogramming, we examined genome-wide DNA methylation …

… of primordial germline cells in a mouse and human embryo … cell elongation, polarity, and
specific molecular pathways. … been identified by genome-wide studies in cell lineages. Generally…

… since one repair pathway, known as base excision DNA repair, … in mammalian germ cells
we generated Ercc1-deficient mice (… To fully exclude a role of nucleotide excision repair, we …

… mice, germ cells are first specified in the developing embryo around embryonic day (E) 6.25
as primordial germ cells … quantification and accurate genome-wide comparison of 5hmC …

… reprogramming, including DNA demethylation involving TET-mediated hydroxylation and,
potentially, base excision repair (… We also isolated germ cells from E31 gonads (Table S1). …

… PGC differentiation into germ cells involves DNA … In mice, the PD pathway reduces
genome-wide methylation to ∼20… focused on base excision as a means of circumventing the …

… methylation patterns in primordial germ cells (PGCs) and … then be repaired by the base
excision repair (BER) pathway. Thus… Genome-wide analysis of mouse embryos from blastocyst to …

… This includes changes on a genome-wide scale and additionally in females the remodeling
… of germ cells along their migration path toward the gonads during epigenetic reprogramming…

… depletion, and active demethylation by repair pathways (Figure 4.4). … In mouse germ cells,
genome-wide passive DNA … DNA demethylation by linked deamination-base excision repair. …