Genomic landscape of intracranial meningiomas
WL Bi, M Abedalthagafi, P Horowitz… - Journal of …, 2016 - thejns.org
Journal of neurosurgery, 2016•thejns.org
Meningiomas are the most common primary intracranial neoplasms in adults. Current
histopathological grading schemes do not consistently predict their natural history. Classic
cytogenetic studies have disclosed a progressive course of chromosomal aberrations,
especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-
generation sequencing approaches has implicated several novel genes whose mutations
underlie a substantial percentage of meningiomas. These insights may serve to craft a …
histopathological grading schemes do not consistently predict their natural history. Classic
cytogenetic studies have disclosed a progressive course of chromosomal aberrations,
especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-
generation sequencing approaches has implicated several novel genes whose mutations
underlie a substantial percentage of meningiomas. These insights may serve to craft a …
Meningiomas are the most common primary intracranial neoplasms in adults. Current histopathological grading schemes do not consistently predict their natural history. Classic cytogenetic studies have disclosed a progressive course of chromosomal aberrations, especially in high-grade meningiomas. Furthermore, the recent application of unbiased next-generation sequencing approaches has implicated several novel genes whose mutations underlie a substantial percentage of meningiomas. These insights may serve to craft a molecular taxonomy for meningiomas and highlight putative therapeutic targets in a new era of rational biology-informed precision medicine.
thejns.org
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