… This makes epigenomic analysis an attractive prospect to further understand the … of obesity.
Furthermore, integrating epigenomic data with known obesity-associated common genetic …

… The genetic aspects of obesity lead to mutations in various genes responsible for controlling
… of genetic determinants of obesity. It includes studies of severe forms of obesity, genome-…

… in obesity. In this study, we evaluated DNA methylation level at the promoter region of the …
subjects comprising 104 of normal and 80 of overweight/obese were enrolled in this study. …

… Understanding the genetic and molecular mechanisms that underlie obesity-related …
promoter Capture Hi–C in human adipocytes to investigate interactions between gene promoters …

… and enhancer regions are implicated in hCS gene expression. A placenta-specific … V and
hCS but not hGH gene promoters, was detected in placentas from lean women (BMI <25 kg/m 2 …

… of the TSS have strong effects on PM20D1 expression in human fat as well as other tissues.
A … variants may account for human genetic associations in this region with obesity as well as …

… other haploinsufficient genes, we targeted Mc4r, where haploinsufficiency leads to … obesity
in mice and humans. CRISPRa-rAAV targeting of the Mc4r promoter rescued the obesity …

… of the etiology of obesity. In conclusion, our analysis identified adipose-specific genes
and revealed evidence for their relationship with genetic causality of obesity, providing an …

… In addition to the phenotypic diversity between the different inbred strains of mice we
analyzed their genetic structure. The residual patterns of heterozygosity within the five breeding …

… In this study, we applied this method to analyze histone methylations in adipose tissue of a
… We analyzed promoter H3K4me3 levels and the gene expression of specific genes related to …