Cerebral oxidative metabolism is decreased with extreme apnoea in humans; impact of hypercapnia

AR Bain, PN Ainslie, RL Hoiland… - The Journal of …, 2016 - Wiley Online Library
… With respect to cerebral energy demands for oxygen, the current world record apnoea … :media:tjp7365:tjp7365-math-0009
may impact CMRO 2 , with hypocapnia increasing, and …

Hypercapnia is essential to reduce the cerebral oxidative metabolism during extreme apnea in humans

AR Bain, PN Ainslie, OF Barak… - … Flow & Metabolism, 2017 - journals.sagepub.com
… , to dissociate the impact of hypoxia and hypercapnia on the … estimations of global CMRO
2 from cerebral drainage solely … only mildly hypocapnic when the convulsions occurred at the …

Severe hypoxaemic hypercapnia compounds cerebral oxidative–nitrosative stress during extreme apnoea: Implications for cerebral bioenergetic function

DM Bailey, AR Bain, RL Hoiland… - The Journal of …, 2024 - Wiley Online Library
… vasoconstriction in response to hypocapnia, hyperoxia and … changes in global CBF (gCBF)
and cerebral metabolic rates … link between hypercapnia and cerebral oxidative metabolism (…

Evidence for direct CO2‐mediated alterations in cerebral oxidative metabolism in humans

HG Caldwell, RL Hoiland, AR Bain, CA Howe… - Acta …, 2024 - Wiley Online Library
… CMRO 2 during hypercapnia, we reasoned that the cerebral … a direct effect of PaCO 2 on
cerebral oxidative metabolism (ie, … well as incidental hypocapnia during mechanical ventilation …

The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status

M Hashem, Y Wu, JF Dunn - International Society on Oxygen Transport to …, 2022 - Springer
… to manipulate CBF, impacts CMRO 2 and the oxidation state of the … Having a means to measure
CBF, CMRO 2 , CCO oxidation state … and the regulation of cerebral oxidative metabolism. …

Hemodynamic and metabolic changes during hypercapnia with normoxia and hyperoxia using pCASL and TRUST MRI in healthy adults

PT Deckers, AA Bhogal… - … Flow & Metabolism, 2022 - journals.sagepub.com
… iso-metabolic, while carbogen appears to elicit a mixed effect; the CMRO 2 reduction during
hypercapnia is … insight into the global hemodynamic and metabolic effects of commonly used …

Influence of hypoxia on cerebral blood flow regulation in humans

CD Steinback, MJ Poulin - Hypoxia: Translation in Progress, 2016 - Springer
cerebrovascular effects of hypoxia. The concomitant ventilatory response during hypoxia
typically results in hypocapnia … to a more global blood flow response elicited by hypercapnia (…

Acute hypoxia increases the cerebral metabolic rate–a magnetic resonance imaging study

MB Vestergaard, U Lindberg… - … flow & metabolism, 2016 - journals.sagepub.com
humans during hypoxia or hypocapnia. In animals studies the published effect of hypocapnia
… blood flow and increased CMRO 2 , suggesting higher oxidative metabolism. We found an …

Human cerebral perfusion, oxygen consumption, and lactate production in response to hypoxic exposure

MB Vestergaard, H Ghanizada, U Lindberg… - Cerebral …, 2022 - academic.oup.com
… CMRO 2 to the individual global brain values. The oxygen … still expect an additive effect
from hypocapnia causing further … humans is not the result of impaired oxidative metabolism or …

Hypercapnia from physiology to practice

A Almanza-Hurtado, C Polanco Guerra… - … Journal of Clinical …, 2022 - Wiley Online Library
cerebral edema and intracranial hypertension [32]. It is worth mentioning that hypocapnia
also has deleterious effects … study showed an association between hypocapnia and in-hospital …