Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans

J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
… by Gcn2 upon exposure to hydrogen peroxide in a dose-… ) ribosome profiling results
indicate that over a third of C. … genome and transcriptome of Cryptococcus neoformans var. …

Unraveling fungal radiation resistance regulatory networks through the genome-wide transcriptome and genetic analyses of Cryptococcus neoformans

KW Jung, DH Yang, MK Kim, HS Seo, S Lim, YS Bahn - MBio, 2016 - Am Soc Microbiol
… in transcriptome profiles during postradiation recovery, cells with or without exposure to …
cerevisiae erg3Δ and erg6Δ mutants were also hypersensitive to hydrogen peroxide (60). …

Transcriptomic analysis reveals the relationship of melanization to growth and resistance to gamma radiation in Cryptococcus neoformans

Z Schultzhaus, A Chen, S Kim, I Shuryak… - Environmental …, 2019 - Wiley Online Library
… observed that the transcriptomic profiles of melanized and non-… neoformans transcriptome
to this dose of γ-radiation, we first … that hydrogen peroxide is being produced during radiation …

[HTML][HTML] Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro

CA Peng, AAE Gaertner, SA Henriquez, D Fang… - PLoS …, 2018 - journals.plos.org
… complexed with iron or copper in the presence of hydrogen peroxide. … Global prevalence
of cryptococcal disease is 5–10% in … methods to study transcription activity in FLC-treated C. …

Comparative Transcriptome Analysis of Clinical and Environmental Strains of Cryptococcus Neoformans and an Investigation on Anti-cryptococcus Activity of Triclosan

E Movahed - 2017 - search.proquest.com
Cryptococcus neoformans is an opportunistic yeast pathogen which causes … different
transcriptome profile of H99 strain compared to H4, S48B and S68B strains. Out of …

[HTML][HTML] Ionizing radiation and chemical oxidant exposure impacts on Cryptococcus neoformans transfer RNAs

M Kelley, MJ Paulines, G Yoshida, R Myers, M Jora… - PloS one, 2022 - journals.plos.org
Transcriptome and tRNA sequencing To generate transcriptome data, duplicate biological
samples exposed to IR doses of 0 Gy, 100 … Thus, we next asked whether the CUB profile for C. …

[HTML][HTML] … neoformans in Galleria mellonella results in increased capsule and intracellular replication in hemocytes, but not increased resistance to hydrogen peroxide

MF Ali, SM Tansie, JR Shahan, RL Seipelt-Thiemann… - Pathogens, 2020 - mdpi.com
… Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals
complex RNA expression and microevolution leading to virulence attenuation. PLoS Genet. …

Transcriptomic response of Cryptococcus neoformans to ecologically relevant nitrogen concentrations

C Bosch, Z Bhana, B Toplis, H Volschenk… - FEMS Yeast …, 2021 - academic.oup.com
… Here, we investigate the global transcriptomic response of C. … To mitigate any ploidy effects
on the transcriptome profile of Cglobal transcriptomic response of Cryptococcus neoformans

[HTML][HTML] Increase of reactive oxygen species contributes to growth inhibition by fluconazole in Cryptococcus neoformans

NH Dbouk, MB Covington, K Nguyen… - BMC microbiology, 2019 - Springer
… antioxidants to alleviate the effects of hydrogen peroxide in C. … and this process is mediated
by a transcription factor Upc2 [23, 24]. … Including Cmt mutants in transcriptional profiling of C. …

Translational Control Promotes Oxidative Stress Resistance in the Human Fungal Pathogen Cryptococcus neoformans

JB Leipheimer Jr - 2020 - search.proquest.com
… suppressed in response to hydrogen peroxide-induced … of translation initiation arrest at 15
minutes, and profiles return to normal … Snf1 kinase is known to promote the transcription of the …