Glucagon-like peptide-1 inhibits prandial gastrointestinal motility through myenteric neuronal mechanisms in humans

MA Halim, M Degerblad, M Sundbom… - The Journal of …, 2018 - academic.oup.com
… of the vagus in the central nervous system (CNS) and parasympathetic control of gastric
emptying. … The glucagon-like peptide 1 receptor agonist exenatide inhibits small intestinal …

Glucagon-like peptide-1 and insulin synergistically activate vagal afferent neurons

Y Iwasaki, C Goswami, T Yada - Neuropeptides, 2017 - Elsevier
… , and inhibition of gastric emptying after meal. Thus, … of GLP-1 and DPP-4 inhibitors on
insulin release, glycemia and … YY 3-36 and glucagon-like peptide-1 on food intake are …

Chronic high fat diet impairs glucagon like peptide-1 sensitivity in vagal afferents

A Al Helaili, SJ Park, MJ Beyak - Biochemical and Biophysical Research …, 2020 - Elsevier
… afferents in mediating the anorexigenic effects of glucagon-like peptide-1 (… -1 inhibited
voltage-gated K + channels, resulting in vagal afferent excitation [28]. This ion channel mechanism

The metabolic role of vagal afferent innervation

TMZ Waise, HJ Dranse, TKT Lam - Nature reviews Gastroenterology & …, 2018 - nature.com
… of cholecystokinin (CCK), glucagon-like peptide 1 (GLP1) and … The support for a vagal
afferent-mediated feeding control is … W and ghrelin inhibit gastric tension receptors to lower the …

Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia

JP Krieger, M Arnold, KG Pettersen, P Lossel… - Diabetes, 2016 - Am Diabetes Assoc
… and satiating peptide glucagon-like peptide 1 (GLP-1). The … the satiating and gastric
emptyinginhibiting effects of … induced reduction in gastric emptying is a major mechanism by …

Endocannabinoid regulation of gastric vagal afferent signalling

SD Christie - 2020 - digital.library.adelaide.edu.au
afferent mediated manners. In the small intestines, glucagon-like peptide 1 (GLP-1), peptide
tyrosine tyrosine (… CCK acts via vagal afferent neurones to inhibit gastrointestinal motility and …

Glucagonlike peptide1 analog, liraglutide, improves visceral sensation and gut permeability in rats

T Nozu, S Miyagishi, S Kumei, R Nozu… - Journal of …, 2018 - Wiley Online Library
… A glucagon-like peptide-1 analog, liraglutide, has been reported to block inflammatory … ,
GLP-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms.28 Therefore, …

[HTML][HTML] GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein

S Hoffman, D Alvares, K Adeli - Molecular Metabolism, 2022 - Elsevier
… One such peptide, glucagon-like peptide (GLP)-1 has been … well-documented effect on
gastric emptying we then sought to … the portal vein stimulates GLP-1R on vagal afferent neurons, …

Endogenous glucagonlike peptide (GLP)‐1 as alternative for GLP‐1 receptor agonists: Could this work and how?

MM Smits, JJ Holst - Diabetes/metabolism research and …, 2023 - Wiley Online Library
… intravenous glucagonlike peptide1 on gastric emptying and … are potent inhibitors of vagally
induced gastric acid secretion … size in the rat via different mechanisms. Endocrinology. 2009;…

The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1

SM Fortin, JC Chen, MC Petticord, FJ Ragozzino… - Science …, 2023 - science.org
… Administration–approved glucagon-like peptide-1 receptor (GLP-… Given the reduction in
gastric emptying by LC Ex-4, we next … We observed that LC Ex-4 stimulates kaolin intake in rats, …