Cholinergic modulation inhibits cortical spreading depression in mouse neocortex through activation of muscarinic receptors and decreased excitatory/inhibitory drive

S Zerimech, O Chever, P Scalmani, L Pizzamiglio… - …, 2020 - Elsevier
… actions, leading in neocortical slices to the generation of … the presence of the glutamate
receptor blocker kynurenic acid (… with our study (anesthetized rats vs acute mouse brain slices). …

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK 1‐WG 4 report of the AES/ILAE Translational Task Force of the ILAE

JV Raimondo, U Heinemann, M de Curtis… - …, 2017 - Wiley Online Library
… electrophysiology of ischemic neocortical rat brain slices did not … the health of primary
glutamatergic neurons. In addition, … of brain slice health is required to evoke epileptiform activity in …

The diverse role of the raphe 5-HTergic systems in epilepsy

H Cheng, C Gao, Q Lou, Z Chen, Y Wang - Acta Pharmacologica Sinica, 2022 - nature.com
… of the septum and glutamatergic neurons in the hippocampus and neocortex. The 5-HT 3 …
on epileptiform activity in rat cortical slices via activation of different 5-HT receptor subtypes. …

[HTML][HTML] Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons

M Pasierski, W Kołba, B Szulczyk - Pharmacological Reports, 2023 - Springer
… Interictal epileptiform events were evoked in cortical slices in … The epileptiform discharges
recorded in this study may be … the effects of glutamate on NMDA receptors/channels because …

[HTML][HTML] AsHC 360 Exposure Influence on Epileptiform Discharges in Hippocampus of Infantile Male Rats In Vitro

L Dong, L Zhao, L Tian, W Zhao, C Xiong… - International Journal of …, 2023 - mdpi.com
… of glutamatergic synapses and lead to changes in cysteine/… ) on hippocampal slices from 8-
to 12-day old Sprague Dawley rats. … on epileptiform discharges could be linked to glutamate

[HTML][HTML] Differential Contribution of Ca2+-Dependent Mechanisms to Hyperexcitability in Layer V Neurons of the Medial Entorhinal Cortex

EC Lin, CL Combe, S Gasparini - Frontiers in cellular neuroscience, 2017 - frontiersin.org
… models show that epileptiform discharges initiate in entorhinal … , horizontal slices were
obtained using a vibratome; the slices … tested the contribution of NMDA glutamatergic receptors by …

TRPV1 channels in nitric oxide-mediated signalling: Insight on excitatory transmission in rat CA1 pyramidal neurons

G Gambino, D Gallo, A Covelo, G Ferraro… - Free Radical Biology …, 2022 - Elsevier
… alone suppressed excitatory transmission in the neocortex [25]. The … transmission of CA1
pyramidal neurons in rat brain slices. … excitatory glutamate release and its post-synaptic activity

[HTML][HTML] Monoaminergic mechanisms in epilepsy may offer innovative therapeutic opportunity for monoaminergic multi-target drugs

D Svob Strac, N Pivac, IJ Smolders, WA Fogel… - Frontiers in …, 2016 - frontiersin.org
… hippocampal 5-HT levels in rats without affecting seizure … receptor subtypes on
epileptiform activity remains elusive. … II–V of human temporal neocortical slices cut from tissue …

[HTML][HTML] ZDHHC8 critically regulates seizure susceptibility in epilepsy

Q Yang, F Zheng, Y Hu, Y Yang, Y Li, G Chen… - Cell death & …, 2018 - nature.com
… manifest epileptiform discharges, we exposed all the slices to a … We measured glutamatergic
synaptic transmission and … of chronic epileptic mice (g) and in the neocortex of TLE patients (…

Sleep deprivation decreases neuronal excitability and responsiveness in rats both in vivo and ex vivo

S Borbély, I Világi, Z Haraszti, Ö Szalontai, T Hajnik… - Brain research …, 2018 - Elsevier
epileptiform activity recordings were made in a random order, it was possible that a slice
study, in parallel with the decreasing glutamate level toward the end of sleep deprivation, …