… antidepressants that … antidepressant effect which is not only faster but also more sustained.
Areas covered: In this paper, the authors summarize the results of studies on antidepressant …

… a rapid and robust antidepressant effect in patients with … two successive courses of
antidepressant treatment (‘treatment-… number of glutamate-based antidepressants have been …

… research into novel glutamate-based therapeutic targets with superior antidepressant effects
but … Here, we review ketamine and other potentially novel glutamate-based treatments for …

… antidepressant glutamate-based agents, such as ketamine [24]. mTOR is a ubiquitous and
highly conserved serine/threonine kinase that functions as a protein synthesis regulator by …

… is seen as a great barrier for tracing glutamatergic transmission and, consequently, for
evaluating the MOA of ketamine and other novel potential glutamate-based antidepressants. …

… has stimulated research into glutamate-based mechanisms of action, new NMDAR antagonists
and glutamate-based drugs are yet to display the fast and long-lasting antidepressant …

… In our opinion, novel glutamate-based antidepressants will find application in the treatment
of mood disorders and present an option will be widely used in clinical practice in the future. …

… as novel antidepressant agents. We critically review the limitations of existing studies of the
clinical effects and hypothesized mechanisms of action of glutamate-based antidepressant …

… basis behind this rapid antidepressant response is under active … features associated with
rapid antidepressant response in MDD … to enable glutamate-based precision therapeutics. …

… Here, we highlight the evidence supporting the antidepressant effects of various … a traditional
antidepressant, 1 underscoring the notion that currently available antidepressants are not …