… block Grb7 mediated interactions in a breast cancer cell line, … A nonphosphorylated
thioether-linked cyclic peptide 1, … even more potent Grb7–SH2 domain bicyclic inhibitors. In this …

… able to bind to the Grb7-SH2 domain with micromolar affinity [… the Grb7-SH2 domain over
other closely related SH2 domains … the peptides to SKBR-3 (HER2+ve breast cancer cell line) …

… the binding of the cyclic peptide G7-18NATE to the Grb7-SH2 wild-… cyclic peptide inhibitors
that are able to inhibit proliferation and migration in breast cancer cell lines and reduce tumor …

… that inhibiting the Grb7-SH2 domain would inhibit breast cancer cell migration as well as other
… This cyclic peptide is 11 amino acids in length (sequence: WFEGYDNTFPC) and is highly …

… in a number of breast cancer cell lines, primary breast tumors 12 … the crystal structure of
G7-B1 in complex with Grb7-SH2 domain, … We have previously shown that the cyclic peptide G7-…

… SH2 domain of Grb7 in Grb7-mediated oncogenesis. Together, these studies emphasize the
critical role of the SH2 domain of Grb7 … -apoptotic effects on cancer cells [50]. Furthermore, …

… bound protein 7 (Grb7) is a modular Src homology domain 2 (SH2)-containing adaptor …
whether a peptide based on the CaM-BD of Grb7 could disrupt relevant tumor cell functions in …

… cancer cell lines overexpress Hax-1, a cytoskeletalassociated protein component. Grb7
interacts with Hax-1 by its RAPH domain … potential effect of Grb7 SH2 domain posttranslational …

… an 11-residue cyclic peptide inhibitor, G7-18NATE, that … In HER2+ breast cancer cells, both
G7-18NATE-P16 and G7-… constructs could still bind to the Grb7-SH2 domain in vitro. For this, …

… also employed to identify potent phosphorylated peptides [11] or cyclic peptides G1TE [12]. …
potent peptide ligands in the binding pockets of Grb2 SH2 domain [13], a number of inhibitors …