[HTML][HTML] Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells
L Dupraz, A Magniez, N Rolhion, ML Richard… - Cell Reports, 2021 - cell.com
Summary Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are
involved in both host defense and regulation of intestinal inflammation. However, factors that
regulate their functions are poorly understood. In this study, we find that the gut microbiota
represses IL-17 production by cecal γδ T cells. Treatment with vancomycin, a Gram-positive
bacterium-targeting antibiotic, leads to decreased production of short-chain fatty acids
(SCFAs) by the gut microbiota. Our data reveal that these microbiota-derived metabolites …
involved in both host defense and regulation of intestinal inflammation. However, factors that
regulate their functions are poorly understood. In this study, we find that the gut microbiota
represses IL-17 production by cecal γδ T cells. Treatment with vancomycin, a Gram-positive
bacterium-targeting antibiotic, leads to decreased production of short-chain fatty acids
(SCFAs) by the gut microbiota. Our data reveal that these microbiota-derived metabolites …
[PDF][PDF] Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal gd T cells
L Dupraz, A Magniez, N Rolhion, P Langella, H Sokol… - hal.sorbonne-universite.fr
SUMMARY Gut interleukin-17A (IL-17)-producing gd T cells are tissue-resident cells that are
involved in both host defense and regulation of intestinal inflammation. However, factors that
regulate their functions are poorly understood. In this study, we find that the gut microbiota
represses IL-17 production by cecal gd T cells. Treatment with vancomycin, a Gram-positive
bacterium-targeting antibiotic, leads to decreased production of short-chain fatty acids
(SCFAs) by the gut microbiota. Our data reveal that these microbiota-derived metabolites …
involved in both host defense and regulation of intestinal inflammation. However, factors that
regulate their functions are poorly understood. In this study, we find that the gut microbiota
represses IL-17 production by cecal gd T cells. Treatment with vancomycin, a Gram-positive
bacterium-targeting antibiotic, leads to decreased production of short-chain fatty acids
(SCFAs) by the gut microbiota. Our data reveal that these microbiota-derived metabolites …
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