… showed that baseline EDSS score, disease duration and frequency of the category
secondary progressive multiple sclerosis with relapse were increased in the HLA-DRB1*15:01∼HLA-…

… -associated HLA-DR15 haplotype also shows high HLA-DRB1 expression and also of the
tightly linked HLA-… HLA-DRB1 at high or low levels in both MS and control cases (figure 2F). As …

… of multiple sclerosis–associated HLA-… of HLA-DRB1*15:01 associated with reduced age
at onset by 1.78 years; P = 1.7 × 10 −2 ), although the association did not remain after multiple …

… and experiential risk factors on multiple sclerosis (MS) onset and course may be key to
our ability to eventually predict and prevent the onset of clinical symptoms. The HLA-DRB1*1501 …

… HLA-DRB1*15:01 (HLA-DR15) to increase the likelihood to develop the autoimmune
disease multiple sclerosis (… In order to gain insights into this synergy, we investigated HLA-DR15 …

… The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01… multiple sclerosis (MS).
The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated …

… between HLA–DRB1*15:01 and age of onset in POMS cases. When we compared the cases
with symptom onset <18 years of age to cases with symptom onset >18 years of age, HLA–…

… HLA-DRB1 locus. Carriage of the DRB1* 1501 risk allele alone was not … associated with
age at disease onset, while the DRB1* 0401 allele was associated with a reduced age at onset …

… a lower age at onset and higher Multiple Sclerosis Severity Score (MSSS). OCB-status
and IgG index are highly correlated probably reflecting the same immunological process [102]. …

… lower age at onset of MS and both lower adolescent summer sun exposure and higher BMI
at the age of … independent effect of HLA-DRB1*1501 on age at onset of MS and indicates that …