… containing either dendron or dendrimer core, in aqueous buffers and plasma in vitro and
in vivo using PET imaging. An excellent clearance from the body was shown in vivo for the …

… pyrrolino-doxorubicin110 and THP111 were bound to HPMA … lines in vitro and enhanced
antitumor effects in vivo. Attachment of … of HPMA copolymers with pH-controlled Dox release by …

… In this study, we compared in vitro and in vivo accumulation … In this system, the cytotoxic
drug is covalently bound to the … structured HPMA-copolymer drug conjugate with doxorubicin (…

… by a hydrazone bond enabling pH-controlled drug release. While the polymer–… HPMA
copolymer–Dox conjugates forming micelles in aqueous solution on their biological effects in vivo. …

… doxorubicin (DOX) bound via pH-sensitive hydrazone bond. We determined the in vitro
and in vivo … investigated the in vitro and in vivo biological activity of two HPMA copolymer-based …

… and a cytotoxicity that was … copolymer carrier, with regard to their uptake by tumor cells,
body distribution, accumulation in tumors, cytotoxicity, and antitumor activity in vitro and in vivo. …

… HPMA-based conjugates of cytotoxic drugs have shown the in vivo ability to deliver the
cytostatic/cytotoxic … Ample evidence shows that HPMA copolymer conjugates carrying Dox or Dtx …

… groups alongside the hydrophilic HPMA copolymer. These groups … Dox release from the
whole micellar system, resulting in both reduced in vitro cytotoxicity and therapeutic effect in vivo…

… backbone biodegradable multiblock HPMA copolymer, paclitaxel … was conjugated to HPMA
via hydrazone bond (HPMA-NH-… The in-vitro cytotoxicity of P6-NPs was evaluated using MTT …

… -lactate) for multimodal in vivo and ex vivo optical imaging [55… sequence for pH-controlled
drug release and enzymatic … In our recent study, PEGylated HPMA-doxorubicin conjugate …