… As we next introduce a robust literature on the roles of Hh signaling during intestinal
development and adult homeostasis, it is important to keep in mind that many different mesenchymal…

… Introduction of Hedgehog signaling pathway The initiation of Hedgehog signaling is based
on the processing of Hedgehog ligands in secretory cells, where a dual lipid-modified amino-…

… muscle cell differentiation induced by Hedgehog signaling. Taken together, our … the
gastrointestinal tract and highlight the functional interplays between Hippo and Hedgehog signaling …

… the major regulators of gastrointestinal tract development is the hedgehog signaling pathway.
The … the role of sonic hedgehog (SHh) signaling 24 and 48 h following intestinal ischemia–…

… intestines, in particular, Hedgehog signaling remains active until death … the intestinal tract
and also the immune system [6-8]. The pathophysiological importance of Hedgehog signaling …

… The Sonic hedgehog (SHH) signaling pathway is essential for embryonic development
and tissue regeneration. The dysfunction of SHH pathway is involved in a variety of diseases, …

… Teleologically, it makes sense that the innate immune system regulates gastric acid because
acid is one of the first defense mechanisms that is activated by the gastrointestinal tract to …

… Hedgehog signaling constitutes a vital pathway regulating patterning and morphogenesis of
… In the adult gastrointestinal tract, Hh signaling plays an important role in homeostasis, as it …

… Experiments that put stress on the adult intestinal epithelium in mice have consistently
revealed a critical role for Hh signaling in the maintenance of intestinal homeostasis. Mice treated …

… be related to the development of the gastrointestinal tract 6 . In … Hedgehog (IHH) and Sonic
Hedgehog (SHH) in the endoderm is essential for the development of the gastrointestinal tract…