Impacts of Porphyromonas gingivalis periodontitis on rheumatoid arthritis autoimmunity

M Mahmoudi, RK Kheder, TA Faraj… - International …, 2023 - Elsevier
gingivalis on rheumatoid arthritis autoimmune response have … gingivalis Peptidyl Arginine
Deaminase (PPAD)) and … Evidence such as the presence and increased titer of anti-P. …

Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection—a missing link for ACPA production

M Jenning, B Marklein, J Ytterberg… - Annals of the …, 2020 - ard.bmj.com
… self-reactive immune responses. The aim of this study was to investigate the autocitrullinated
prokaryotic peptidylarginine deiminase (… . Heightened immune response to autocitrullinated

Correspondence to 'Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection—a missing link for ACPA production'

KSK Ma, CH Chiang, YW Chen… - Annals of the Rheumatic …, 2023 - ard.bmj.com
… by which autocitrullinated prokaryotic peptidyl arginine deiminase (… , we found host responses
against bacterial infections that … This activation primarily occurs through increased cellular …

Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis

T Stobernack, C Glasner, S Junker… - Journal of proteome …, 2016 - ACS Publications
… that may impact the host’s immune system by increasing the level of … colleagues suggested
that this autocitrullination could be an … Porphyromonas gingivalis peptidylarginine deiminase …

The P. gingivalis Autocitrullinome Is Not a Target for ACPA in Early Rheumatoid Arthritis

E Muñoz-Atienza, MB Flak, J Sirr… - Journal of dental …, 2020 - journals.sagepub.com
host immune response against pathogenic microbes, including … patients, we found that the
autocitrullinated proteome of P. … Porphyromonas gingivalis peptidylarginine deiminase (PPAD…

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

YC Chow, HC Yam, B Gunasekaran, WY Lai… - Frontiers in Cellular …, 2022 - frontiersin.org
… deiminase (PPAD) could further cause dysregulation to the host immune system by … ,
whereby the N-terminal serves to protect PPAD from autocitrullination. The ability of N-terminal …

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells …

N Sherina, C de Vries, N Kharlamova, N Sippl… - Frontiers in …, 2022 - frontiersin.org
… reflect a true bacterial immune response rather than background … by autocitrullination, as
studies of recombinant full-length P.… , citrullinated Porphyromonas gingivalis peptidylarginine

Porphyromonas gingivalis and its LPS differentially regulate the expression of peptidyl arginine deiminases in human chondrocytes

R Elkaim, IM Bugueno-Valdebenito… - … Immunity, 2017 - journals.sagepub.com
increased in only … immune response amplified by recruiting inflammatory cells to the target
tissue (periodontium or synovial membrane). These cellular and humoral immune reactions

Oral biofilms from symbiotic to pathogenic interactions and associated disease–connection of periodontitis and rheumatic arthritis by peptidylarginine deiminase

K Kriebel, C Hieke, B Müller-Hilke, M Nakata… - Frontiers in …, 2018 - frontiersin.org
… of the pathobiont Porphyromonas gingivalis with host cells, as … lesion, along with increased
infiltration of macrophages and T … from the host immune system, it has been shown that P. …

Citrullinome of Porphyromonas gingivalis outer membrane vesicles: confident identification of citrullinated peptides

…, JZ Kaczmarek, J Potempa, P Højrup - Molecular & Cellular …, 2020 - ASBMB
… but increased the confidence of the validation. A new two-dimensional separation system
) The best characterized is Porphyromonas gingivalis peptidyl arginine deiminase (PPAD). …