… mutations result in nonviable phenotypes with dysplastic formation of the lungs, pituitary and
thyroid … article reviewed the heterogeneity of lung disease in NKX2–1 mutations, with a short …

… Phenotypic heterogeneity in tumor cell populations that … the phenotypic heterogeneity in
subtypes of thyroid cancers. … and inhibited the lung metastasis development in a thyroid cancer …

… The aim of this study was to describe the pulmonary phenotypes in patients with NKX2-1
mutations, including the clinical and radiological features, course of treatment and outcome. …

… BLTS shows a striking phenotypic heterogeneity, both in the number of organs affected
and in the severity of the disease. Most patients present with benign hereditary chorea and …

… of traditionally common cancers such as melanoma and breast, lung, … phenotypic heterogeneity
of the tumour centre and tumour border was observed in a study of encapsulated thyroid …

… NKX2-1 mutations are associated to the “brain-lung-thyroid” syndrome, a triad characterized
… the phenotypic heterogeneity (either inter or intra-familial) of subjects harboring mutation of …

… Our study identifies genetic determinants of TBX4 disease heterogeneity, inclusive of …
associated with later-onset lung disease. It draws important conclusions on genotype–phenotype …

… gene expression with these mutations contributes to the respiratory phenotypes observed. …
Heterogeneous pulmonary phenotypes associated with mutations in the thyroid transcription …

… Thyroid dyshormonogenesis is a heterogeneous group of hereditary diseases … and lung,
which is why some mutations in these genes cause syndromic phenotypes that are associated …

… Although PAH is heterogeneous, genetic defects relevant to pulmonary … Mutations in
the bone morphogenetic protein (BMP) receptor type 2 gene (BMPR2) and other BMP-associated …