Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

EM Overway, KJ Bosma, DP Claxton, JK Oeser… - Journal of Biological …, 2022 - ASBMB
… mutations using a novel in situ assay for glucose-6-phosphatase activity and the effect of
mutations in conserved human G6PC1/G6PC2 amino acids on G6PC2 protein expression. …

Identification and Characterization of the Glucose-6-Phosphate Dehydrogenase Gene Family in the Para Rubber Tree, Hevea brasiliensis

X Long, B He, Y Fang, C Tang - Frontiers in plant science, 2016 - frontiersin.org
Reflecting what was found in the cDNA sequences, a high similarity, ranging from 45.3 to
76.1%, was shared among the four HbG6PDH proteinadaptation of plants to various habitats. …

[HTML][HTML] The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice

F Rajas, R Dentin, AC Miliano, M Silva, M Raffin… - Molecular …, 2021 - Elsevier
adaptation promoted by the low level of lipids to increase fatty acid uptake. Moreover, it should
be noted that the expression of … as a vital organ, reflecting the exhibition of courage and of …

Master role of glucose-6-phosphate in cell signaling and consequences of its deregulation in the liver and kidneys

F Rajas, G Mithieux - Molecular Nutrition: Carbohydrates, 2019 - Elsevier
Glucose-6-phosphatase is a key enzyme for endogenous … Thus these two pathologies
could be considered as “mirror” … GCK, could represent an interesting adaptation during fasting. …

Insulin-mediated glycemic responses and glucose homeostasis in black sea bream (Acanthopagrus schlegelii) fed different carbohydrate sources

S Taj, X Li, Q Zhou, M Irm, Y Yuan, B Shi, Y Shen, M Jin… - Aquaculture, 2021 - Elsevier
Genes such as glucose 6 phosphatase (g6pc) and phosphoenol … has certain adaptability
to elevated glucose levels. … The tolerance to glucose is also reflected by an enhanced use of …

Metabolic adaptation establishes disease tolerance to sepsis

S Weis, AR Carlos, MR Moita, S Singh, B Blankenhaus… - Cell, 2017 - cell.com
… inhibition of the liver glucose-6-phosphatase (G6Pase), and in … a crosstalk between adaptive
responses controlling iron and … Characteristics of clinical sepsis reflected in a reliable and …

The regulatory effect of saffron stigma on the gene expression of the glucose metabolism key enzymes and stress proteins in streptozotocin-induced diabetic rats

M Motamedrad, A Shokouhifar… - Research in …, 2019 - journals.lww.com
… In contrast, glucose 6-phosphatase (G6Pase) is one of the enzymes in gluconeogenesis
pathway that causes an increase in blood glucose. Considerable evidence has suggested …

The role of glucose-6-phosphatase catalytic domain in glucose homeostasis

N Ng - 2016 - ora.ox.ac.uk
… control than FG as it reflects the average plasma glucose concentration over the preceding
2-3 months. Individuals with raised blood glucose levels not high enough for a diagnosis of …

Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver

Y Pan, A Hatano, S Ohno, K Morita, T Kokaji… - npj Systems Biology …, 2024 - nature.com
… 1, G6pc Glucose-6-phosphatase, Igfbp1 insulin-like growth factor binding protein 1, …
metabolism presented in this study may not reflect the direct causal relationship and should …

ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing

R Imle, BT Wang, N Stützenberger, J Birkenhagen… - Scientific reports, 2019 - nature.com
… of ER stress response that induces an adaptive but not apoptotic response. However, upon
… -6-phosphate translocase (G6PT) and glucose-6-phosphatase (G6PC1). Similar to ADPGK, …