Reinforcing effectiveness of nicotine in nonhuman primates: effects of nicotine dose and history of nicotine self-administration

SJ Kohut, J Bergman - Psychopharmacology, 2016 - Springer
… ), lower, not higher, doses do not conform to the unit price analysis. In contrast, our results
suggest that lower doses of nicotine have greater reinforcing effectiveness than higher doses. …

Nicotine acutely enhances reinforcement from non-drug rewards in humans

KA Perkins, JL Karelitz, MC Boldry - Frontiers in psychiatry, 2017 - frontiersin.org
… also acutely enhances the reinforcing efficacy of non-… reinforcement-enhancing effects
of nicotine was due to procedural differences rather than lack of generalizability from non-human

Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates

B Le Foll, SI Chefer, AS Kimes, EA Stein… - …, 2016 - Springer
… In order to test this hypothesis, we trained squirrel monkeys to self-administer nicotine under
a fixed ratio schedule of reinforcement with 1-h daily sessions. Pre-exposure baseline and …

Effects of lorcaserin (Belviq®) on nicotine-and food-maintained responding in non-human primates

DS Jacobs, CE Barkin, MR Kohut, J Bergman… - Drug and alcohol …, 2017 - Elsevier
… The present study was conducted to determine the efficacy and selectivity of acute or
continuous lorcaserin treatment for decreasing the reinforcing effects of nicotine in a primate

[HTML][HTML] Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models

LC Smith, O George - Neuropharmacology, 2020 - ncbi.nlm.nih.gov
… pathway and show efficacy in reducing nicotine addiction-like … , higher oxidation, and
inflammation that are associated with … primates (Table 6). The majority of preclinical work on anti-…

Reinforcing and adverse observable effects of nicotine and minor tobacco alkaloids in squirrel monkeys

EL Burke, RI Desai - Drug and Alcohol Dependence, 2024 - Elsevier
… Given the lack of information available on the behavioral pharmacology of minor tobacco
alkaloids alone in a primate species, as a first step we sought to test several prominent minor …

Attenuating nicotine reinforcement and relapse by enhancing endogenous brain levels of kynurenic acid in rats and squirrel monkeys

ME Secci, A Auber, LV Panlilio, GH Redhi… - …, 2017 - nature.com
… The currently available antismoking medications have limited efficacy and often fail to … active
constituent of marijuana) in rodents and non-human primates, and that these effects are due …

Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques

SM Evans, RW Foltin, MJ Hicks, JB Rosenberg… - Pharmacology …, 2016 - Elsevier
reinforcing effects of cocaine in rats. The goal of this study was to extend and validate dAd5GNE
vaccine efficacy in non-human primates. … stimulus effects of nicotine in squirrel monkeys. …

Differential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on nicotine versus cocaine self-administration and relapse in squirrel monkeys

Z Justinova, B Le Foll, GH Redhi, A Markou… - …, 2016 - Springer
… a non-human primate model of nicotine self-administration. … This confirms the effectiveness
of mGluR2/3 stimulation in … in non-human primate models of nicotine reinforcement and …

Influence of experimental history on nicotine self-administration in squirrel monkeys

RI Desai, KA Sullivan, SJ Kohut, J Bergman - Psychopharmacology, 2016 - Springer
nicotine and anatabine had reinforcing effects in both groups. However, optimal doses of
nicotine and anatabine maintained significantly higher … allotment of high protein primate chow (…